VZL 2003, 72(3):129-131
AN IN VITRO COMPARISON OF THE REACTIVATOR EFFICACY OF POTENTIAL SYMMETRIC BISQUATERNARY ACETYLCHOLINESTERASE REACTIVATORS WHICH DIFFER IN THEIR CONNECTING CHAIN LENGTH
- Kamil Kuča
ORCID..., Jiří Cabal - Katedra toxikologie Vojenské lékařské akademie J. E. Purkyně, Hradec Králové
Byla porovnána reaktivační účinnost dvou potenciálních reaktivátorů acetylcholinesterázy inhibované nervově paralytickou látkou VX — I,3-bis(2-hydroxyiminomethypyridinium) propan dibromidu a 1,4-bis(2-hydroxyiminomethypyridinium) butan dibromidu. Ukázalo se, že oxim s delším spojovacím řetězcem je lepším reak, tivátorem VX-inhibovane' acetylcholinesterázy.
Keywords: Acetylcholinesteráza; Látka VX; Oximy; Reaktivace
The reactivation potencies of two potential reactivators of the VX-inhibited acetycholinesterase — I.3-bis(2-hydroxyiminomethypyridinium) propane dibromide and 1.4-bis(2-hya'roxyiminomethypyridinium) butane dibromide were compared. Oxime with its longer connecting chain seems to be a better reactivator of VX-inhibited acetylcholinesterase.
Keywords: Acetylcholinesterase; VX agent; Oximes; Reactivation
Published: June 1, 2003 Show citation
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