VZL 2003, 72(5):236-238
POSSIBILITIES OF 1-(4-HYDROXYIMINOMETHYLPYRIDINIUM)-3(4-CARBAMOYLPYRIDINIUM)-PROPANE DIBROMIDE
- Jiří Bielavský, Kamil Kuča
ORCID..., Jiří Cabal, Marcela Bielavská - Katedra toxikologie Vojenské lékařské akademie J. E. Purkyně, Hradec Králové
Byla provedena syntéza a in vitro testování nového potenciálního reaktivátoru acetylcholinesterazy (AChE) — I-(4-hydroxyiminomethylpyridinium)-3-(4—karbamoylpyridinium)-propan dibromidu. Reaktivační účinnost u AChE inhibované sarinem a VX je srovnatelná se standardním reaktivátorem HI-6, u tabunu je reaktivační účinnost lepší a u cyklosarinu je nedostatečná.
Keywords: Acetylcholinesteráza; In vitro; Organofosfát; Oxim; Reaktivace; HI-6
Synthesis and in vitro testing of a new potential acetylcholinesterase (AChE) reactivator — I —(4-hydroxyimi-nomethylpyridinium)-3-(4-carbamoylpyridinium)-propane dibromide have been carried out. Its reactivation efficacy to sarin-inhibited AChE and VX is comparable to that of the standard reactivator HI-ó. Its reactivation efficacy to sarin is better than its efficacy to oxime HI-6 and its reactivation efficacy to cyclosarin is insufficient.
Keywords: Acetylcholinesterase; In vitro; Organophosphate; Oxime; Reactivation; HI-6
Published: October 1, 2003 Show citation
