VZL 2006, 75(3):92-100

Selected Aspects Influencing the Quality of Life in Patients with Multiple Myeloma and Malignant Lymphoma after the Hematopoietic Stem cell Transplantation

Ladislav Slováček1,2, Birgita Slováčková3, Ladislav Jebavý1,2
1 Univerzita obrany, katedra válečného vnitřního lékařství Fakulty vojenského zdravotnictví, Hradec Králové
2 Oddělení klinické hematologie II. interní kliniky, Fakultní nemocnice a Lékařská fakulta UK, Hradec Králové
3 Psychiatrická klinika, Fakultní nemocnice a Lékařská fakulta UK, Hradec Králové

Studie analyzuje vliv vybraných aspektů na globální kvalitu života u nemocných s mnohočetným myelomem a maligním lymfomem po transplantaci krvetvorných buněk na Oddělení klinické hematologie II. interní kliniky Fakultní nemocnice a Lékařské fakulty Univerzity Karlovy v Hradci Králové v letech 2001-2003. Celkový počet respondentů byl 80, návratnost dotazníků byla 70%, tj. od 56 respondentů - 32 s mnohočetným myelomem, věkový medián byl 60 let a 24 s maligním lymfomem, věkový medián byl 46,5 roku. K otestování respondentů byla použita česká verze mezinárodního generického dotazníku European Quality of Life Questionnaire - Version EQ-5D. Vliv vybraných aspektů na globální kvalitu života (typ transplantace krvetvorných buněk - autologní, alogenní, věk, pohlaví, vzdělání, rodinný stav, religiozita, nikotinismus, typ onemocnění a časový odstup od provedení transplantace krvetvorných buněk byl proveden analýzou rozptylu. Z uvedených aspektů byla prokázána statisticky významná závislost EQ-5D indexu a EQ-5D VAS na věku a typu onemocnění u obou kohort nemocných (v obou případech p < 0,01) a na nikotinismu u nemocných s mnohočetným myelomem (v obou případech p < 0,05). Vliv ostatních aspektů se jako statisticky významný neprokázal. Globální kvalita života nemocných s mnohočetným myelomem po transplantaci krvetvorných buněk je nižší v porovnání s nemocnými s maligním lymfomem po transplantaci krvetvorných buněk na našem oddělení, o čemž vypovídají průměrné hodnoty EQ-5D indexu (68,9 % u nemocných s mnohočetným myelomem a 82,7 % u nemocných s maligním lymfomem) a průměrné hodnoty EQ-5D VAS (66,6 % u nemocných s mnohočetným myelomem a 76,7 % u nemocných s maligním lymfomem).

Keywords: Kvalita života; Mnohočetný myelom; Maligní lymfom; Transplantace krvetvorných buněk; Dotazníky kvality života

Aim: The study analyses the influence of selected aspects on the global quality of life in patients with multiple myeloma and malignant lymphoma after the hematopoietic stem cell transplantation at the Department of Clinical Hematology of the Second Internal Clinic of the University Hospital and Medical Faculty of Charles University in Hradec Králové from 2001 to 2003.

Patients and Methods: The total number of respondents after the transplantation was 80 and the return rate of questionnaire was 70% (56 respondents - 32 with multiple myeloma - average age was 60 years and 24 with malignant lymphoma - average age was 46,5 years). The Czech version of the international generic European Quality of Life Questionnaire - Version EQ-5D was used. The influence of monitored aspects (the type of transplantation - autologous, allogenous, age, sex, education, marital status, religion, nicotinism, the type of disease and the time-gap from the transplantation) on the global quality of life in patients was performed by means of analysis of variance.

Results: The above-mentioned aspects proved statistically significant dependence of EQ-5D index and EQ-5D VAS on the age (in both cases p < 0,01) and on the type of disease (in both cases p < 0,01) in both groups of patients and on nicotinism in patients with multiple myeloma (in both cases p < 0,05). EQ-5D index and EQ-5D VAS significantly decrease with increasing age and type of disease in both groups and nicotinism in patients with multiple myeloma. The influence of other factors on EQ-5D index and EQ-5D VAS was not proven as statistically significant.

Conclusion: The global quality of life in patients with multiple myeloma after the hematopoietic stem cell transplantation is lower than in patients with malignant lymphoma after the transplantation performed at our department, what show us the average values of EQ-5D index (68,9 % in patients with multiple myeloma and 82,7 % in patients with malignant lymphoma) and the average values of EQ-5D VAS (66,6 % in patients with multiple myeloma and 76,7 % in patients with malignant lymphoma).

Keywords: Quality of life; Multiple myeloma; Malignant lymphoma; Hematopoietic stem cell transplantation; Quality of life questionnaire

Received: November 25, 2005; Published: December 1, 2006  Show citation

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Slováček, L., Slováčková, B., & Jebavý, L. (2006). Selected Aspects Influencing the Quality of Life in Patients with Multiple Myeloma and Malignant Lymphoma after the Hematopoietic Stem cell Transplantation. Vojenské Zdravotnické Listy, 75(3-4), 92-100
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