VZL 2006, 75(3):126-129

Phosgene: Health Hazard

Magdaléna Horáková, Miroslava Jandová, Helena Kociánová
Zdravotně sociální fakulta Jihočeské univerzity, České Budějovice

Fosgen (karbonyl chlorid, CAS 75-44-5) je vysoce reaktivní, dříve bojový otravný plyn, dnes již historického významu, v současnosti má však význam průmyslový. Je to silný plicní iritant, který může vyvolat apoptózu epiteliálních a endoteliálních plicních buněk, což je zřejmě mechanismus vzniku fosgenem indukovaného plicního edému. Tento článek se zabývá stručnou historií, toxicitou, klinickými projevy a obecnými principy terapie fosgenových intoxikací.

Keywords: Fosgen; Plicní edém; Toxicita; Terapie

Phosgene (carbonyl chloride, CAS 75-44-5) is highly reactive, formerly warfare toxic gas of historical significance but current industrial importance. It is a strong lung irritant which can induce pulmonary epithelial and endothelial cell apoptosis, suggesting that the mechanism of phosgene-induced pulmonary edema causes apoptosis of lung cells. This article deals with history, toxicity, clinical symptoms of the disease, and general concepts in therapy of phosgene intoxications.

Keywords: Phosgene; Pulmonary edema; Toxicity; Therapy

Received: March 10, 2006; Published: December 1, 2006  Show citation

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Horáková, M., Jandová, M., & Kociánová, H. (2006). Phosgene: Health Hazard. Vojenské Zdravotnické Listy, 75(3-4), 126-129
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