VZL 2007, 76(6):232-235

Alfa-Latrotoxin

Jiří Patočka ORCID...
Katedra radiologie a toxikologie Zdravotně sociální fakulty Jihočeské univerzity, České Budějovice

Alfa-latrotoxin je 130 kDa proteinový toxin z jedu pavouků rodu Latrodectus (snovačka) a je to jediný protein jejich jedu, který účinkuje na savce. Uplynulo již více než 30 let od doby, kdy byl alfa-latrotoxin izolován z jedové žlázy pavouka Latrodectus tredecimguttatus, zvaného černá vdova. Je to jeden z nejjedovatějších živočišných jedů a je zodpovědný za tisíce otrav způsobených pavouky tohoto rodu. Toxin je široce využíván při studiu uvolňování neurotransmiterů, ale jeho přesný mechanismus účinku není dosud znám.

Keywords: Biotoxin; Alfa-latrotoxin; Latrodectus; "Černá vdova"; Latrodektismus

Alfa-latrotoxin is a 130 kDa protein toxin from the Latrodectus spider venom, and it is the only protein of the venom that affects mammals. It has been more than 30 years since alfa-latrotoxin was first isolated from venom glands of the female spider Latrodectus tredecimguttatus, called "black widow". It is one of the most poisonous animal toxins, and it is liable for thousands of envenomenations due to spiders of Latrodectus genus. The toxin is widely used to induce and study the neurotransmitter release, but the precise molecular mechanism of its effect is not fully determined.

Keywords: Biotoxin; Alfa-latrotoxin; Latrodectus; "Black widow"; Latrodectism

Received: July 16, 2007; Published: December 1, 2007  Show citation

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Patočka, J. (2007). Alfa-Latrotoxin. Vojenské Zdravotnické Listy, 76(6), 232-235
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