Vojenské Zdravotnické Listy, 2007 (vol. 76), issue 6
Colour Supplement
VZL 2007, 76(6):I-IV 
Predictive and Prognostic Factors of Invasive Breast Cancer in Practice
Petr Cinek, Stanislav Filip
VZL 2007, 76(6):205-210
The invasive breast cancer is a heterogenous disease. Patients come not only with different stages of the disease, but also their carcinomas are various in growth speed, metastatic potency and other biological attributes. A number of important prognostic and predictive factors was determined for breast cancer. The main factors are clinical stage, size of primary tumor, involvement of regional lymph nodes, histological type of carcinoma, grade, status of steroid and HER-2/neu receptors expression, invasion into blood and lymph vessels, proliferative markers, biological and hormonal age of patients, and levels of serum markers. In our study we evaluated...
The Membrane HER-2/neu Receptor - Structure and Function, Prognostic and Predictive Role for Invasive Breast Cancer Patients
Petr Cinek, Stanislav Filip
VZL 2007, 76(6):211-215
The HER-2/neu receptor, a member of transmembrane HER receptors family, plays a very important role in activation of the signalling downstream path which mediates the transfer of extracellular signal into the cell nucleus. The physiological processes, leading to receptor activation, as well as its whole signalling cascade are understood well today. The increased HER-2/neu activation, in the case of its abundance in cellular membrane, participates in complicated processes of cancerogenesis and is liable for the formation of tumor cells with a more malignant phenotype and more aggressive biological behaviour.The status of HER-2/neu expression in invasive...
Incidence of Ochratoxin A in Czech Regions
Helena Šultesová, Miroslav Brndiar, Jaroslav Kačerovský, František Malíř, Jiří Knížek, Ladislav Jebavý, Jan M. Horáček
VZL 2007, 76(6):216-220
The Department of Military Internal Medicine of the Faculty of Military Health Sciences University of Defence has been working on the research of ochratoxin A (OTA) in cooperation with the Health Institute in Hradec Kralove for several years. OTA belongs to mycotoxins and is produced by Aspergillus and Penicillinum fungi. It occurs in common food; its presence has been proved in the serum of healthy people. Among experimentally proved undesirable effects of OTA on the organism belong: nephrotoxicity, genotoxicity, teratogenicity, immunosuppressive effects and also possible acute intoxication.The study involves the development of OTA level in the serum...
Smokeless Tobacco: Another Form of Hazardous Tobacco
Sajith Vellappally, Zdeněk Fiala, Jindra Šmejkalová, Vimal Jacob, Pilathadka Shriharsha
VZL 2007, 76(6):221-226
This review deals with the smokeless tobacco products, their use, composition, systemic and oral diseases associated with it. It is evident that smokeless tobacco is carcinogenic to human and causes various systemic and oral diseases. One of the major cancers caused by smokeless tobacco use is oral cancer and other oral diseases like leucoplakia, dental caries, smokeless keratosis, and other negative influences of smokeless tobacco on oral cavity including staining of teeth, bad breath, mouth sores, attrition and abrasion. This review also tries to describe the possible tobacco cessation intervention in dental office.
Czech Republic, Rabies and the "rabies free" status
Roman Šindelář, Martina Pokorná, Marie Hiršová, Roman Chlíbek, Petr Drahotský
VZL 2007, 76(6):227-231
In 2004, the Czech Republic was declared a rabies free country. However, in 2005 some girls got into contact with a sick bat that had been infected by this virus. The declared "rabies free" status proceeds from the definition of the International Institute for Animal Infection which does not, unlike the status of the World Health Organization, require rabies negativity in bats. This condition calls for an increased attention to contacts with bats not only in the Czech Republic, but also within all Europe. In addition, this event was accompanied by transmission of rabies during transplantations in the USA and Germany, which increased further demands...
Alfa-Latrotoxin
Jiří Patočka
VZL 2007, 76(6):232-235
Alfa-latrotoxin is a 130 kDa protein toxin from the Latrodectus spider venom, and it is the only protein of the venom that affects mammals. It has been more than 30 years since alfa-latrotoxin was first isolated from venom glands of the female spider Latrodectus tredecimguttatus, called "black widow". It is one of the most poisonous animal toxins, and it is liable for thousands of envenomenations due to spiders of Latrodectus genus. The toxin is widely used to induce and study the neurotransmitter release, but the precise molecular mechanism of its effect is not fully determined.
Characterization of Preparation of Equine Serum Butyrylcholinesterase in vitro and Its Blood Levels in Rats
Lucie Bartošová, Jiří Bajgar
VZL 2007, 76(6):236-241
Michaelis constant in two concentration ranges of substrate (Km 59.7 μM and Kss 1.02 mM) evidencing activation of the enzyme by substrate and pI50 (7.06 nM) value for preparation of equine butyrylcholinesterase were determined in vitro. Activities of cholinesterases in the blood of rats were determined following i. p. administration lasting 72 hours after the administration.
Report from the 12th International Congress of the European Burns Association in Budapest
Leo Klein
VZL 2007, 76(6):242-243
The 7th Annual Conference of the Society of Military Doctors, Pharmacists and Veterinary Doctors of the Czech Purkyně Medical Society in Hradci Králové
Leo Klein
VZL 2007, 76(6):244
Napoleon Contra Lice
Vladimír Měrka, Leo Klein, Hana Hlaváčková
VZL 2007, 76(6):245-246
Excavation of a mass grave of Napoleon's soldiers in Vilnius showed their massive infestation with body lice and evidence for a severe typhus epidemic which contributed essentially to Napoleon's crushing defeat in Russia 1812.
Vibration Vest - Future of Military Communication?
Jiří Patočka, Daniel Jun
VZL 2007, 76(6):247