VZL 2010, 79(1):2-8

A Comparison of the Neuroprotective Efficacy of Newly Synthesized Oximes (K250, K251) and Oximes Introduced into the Czech Army (Obidoxime, HI-6) in Tabun-Poisoned Rats

Jiří Kassa ORCID...1, Jana ®ďárová Karasová ORCID...1, Sandra Tesařová3, Kamil Musílek ORCID...1, Kamil Kuča ORCID...2, Jiří Bajgar1
1 Univerzita obrany, Fakulta vojenského zdravotnictví, katedra toxikologie, Hradec Králové
2 Univerzita obrany, Fakulta vojenského zdravotnictví, Centrum pokročilých studií, Hradec Králové
3 Sedmá polní nemocnice Armády České republiky, Hradec Králové

Na samcích potkana kmene Wistar byl testován neuroprotektivní účinek nově syntetizovaných oximů (K250, K251) a srovnáván s efektem oximů zavedených do zdravotnické výbavy AČR jako antidotum první pomoci (obidoxim) nebo lékařské pomoci (HI-6). Schopnost oximů eliminovat tabunem navozené akutní příznaky neurotoxicity byla hodnocena pomocí funkční pozorovací baterie 24 hodin po otravě tabunem. Získané výsledky ukázaly, ľe neuroprotektivní účinek nově syntetizovaného oximu K251 je o něco vyąąí neľ účinek obidoximu a oximu HI-6, ale rozdíl v neuroprotektivní účinnosti výąe uvedených oximů nebyl přílią výrazný. Oxim K250 je naopak méně účinný při eliminaci tabunem vyvolaných příznaků akutní neurotoxicity ve srovnání s obidoximem i oximem HI-6.

Keywords: Tabun; Funkční pozorovací baterie; HI-6; Obidoxim; K250; K251; Atropin; Potkan

The neuroprotective efficacy of newly synthesized oximes (K250, K251) and the oximes introduced into the Czech Army for the first aid (obidoxime) and medical aid (HI-6) was compared in male Wistar rats. The potency of oximes to eliminate tabun-induced acute neurotoxic effects was evaluated with the help of a functional observational battery 24 hours following tabun intoxication. The obtained results demonstrate that the neuroprotective efficacy of newly synthesized oxime K251 is a little higher in comparison with the potency of obidoxime and HI-6 to eliminate tabun-induced acute neurotoxicity but the difference is not too high. On the contrary, another newly synthesized oxime K250 is less effective than obidoxime and HI-6 in elimination of tabun-induced acute neurotoxic effects.

Keywords: Tabun; Functional observational battery; HI-6; Obidoxime; K250; K251; Atropine; Rat

Received: March 31, 2009; Published: March 1, 2010  Show citation

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Kassa, J., ®ďárová Karasová, J., Tesařová, S., Musílek, K., Kuča, K., & Bajgar, J. (2010). A Comparison of the Neuroprotective Efficacy of Newly Synthesized Oximes (K250, K251) and Oximes Introduced into the Czech Army (Obidoxime, HI-6) in Tabun-Poisoned Rats. Vojenské Zdravotnické Listy, 79(1), 2-8
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