MMSL 2012, 81(2):46-55 | DOI: 10.31482/mmsl.2012.006

FRANCISELLA TULARENSIS - 100 YEARS: TULAREMIA RESEARCH IN FORMER CZECHOSLOVAKIA AND IN THE CZECH REPUBLICReview article

Aleš Macela ORCID...1, Jiří Stulík ORCID...1, Zuzana Kročová ORCID...1, Michal Kroča2, Klára Kubelková ORCID...3*
1 Institute of Molecular Pathology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
2 Center of Biological Defence, Central Military Institute of Health, Techonin, Czech Republic
3 Center of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic

The history of national tularemia research started in 1936 when the first outbreak was recognized in south-east Moravia. Since then in average about one hundred cases have been recorded annually. As tularemia was endemic in former Czechoslovakia, three research groups which concentrated on this disease were formed during decades. The first two groups have worked from sixties and were associated with Jiri Libich (Prague) and Darina Gurycova (Bratislava). The third group which concentrated on the research of natural foci started during late seventies in Valtice (Zdenek Hubalek). The experimental research was, and still is, mainly associated with military research, recently with the Proteomic Center (Faculty of Military Health Sciences, University of Defence) in Hradec Kralove. This center opens molecular approaches to the analysis of Francisella tularensis microbes on one side and the studies on mutual host-pathogen interaction on the other side. One of the significant aims of the research is searching for the new typing and diagnostic markers of Francisella tularensis for the military and medical practice. Thus, scientists from former Czechoslovakia and the Czech Republic contributed significantly to current knowledge on Francisella pathogenesis and their results were highly appraised by international scientific community.

Keywords: Francisella tularensis; tularemia; former Czechoslovakia; Czech Republic

Received: February 3, 2012; Revised: May 15, 2012; Published: June 8, 2012  Show citation

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Macela, A., Stulík, J., Kročová, Z., Kroča, M., & Kubelková, K. (2012). FRANCISELLA TULARENSIS - 100 YEARS: TULAREMIA RESEARCH IN FORMER CZECHOSLOVAKIA AND IN THE CZECH REPUBLIC. MMSL, 81(2), 46-55. doi: 10.31482/mmsl.2012.006
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