MMSL 2012, 81(2):82-83 | DOI: 10.31482/mmsl.2012.011
NATURAL PHOSPHOR ESTER CHOLINESTERASE INHIBITORSLetter to the editor
- Department of Cellular Biology & Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami
It was with great interest and pleasure that I read the contribution of Patocka et al. in the MMSL reviewing the literature on anatoxin-A(s) an Organophosphorus Cholinesterase Inhibitor (OP) of natural origin produced by cyanobacteria (formerly identified as algae). Anatoxin-A(s), a phosphate ester of imidazole (Figure 1), is a very interesting substance that lacking the ability to cross the bloodbrain-barrier selectively and irreversibly inhibits the cholinesterases ...
Received: January 9, 2012; Revised: May 15, 2012; Published: June 8, 2012 Show citation
References
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