MMSL 2012, 81(3):96-99 | DOI: 10.31482/mmsl.2012.015

IN VITRO SKIN PERMEATION OF DETERGENTS AND DETERGENT-BASED DECONTAMINATION MIXTUREOriginal article

Jan Misík ORCID...1*, Růžena Pavlíková ORCID...1, Jiří Cabal1, Denis Josse2, Kamil Kuča ORCID...1,3
1 Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
2 Service de Santé et de Secours Médical du Service d'Incendie et de Secours des Alpes-Maritimes (SDIS06), 140 Avenue Maréchal de Lattre de Tassigny, BP99, 06271 Villeneuve-Loubet Cedex, France
3 Biomedical Research Centre, University Hospital; Hradec Kralove; Czech Republic

The purpose of this study was to assess the ability of selected detergents (althosan MB 50%, triton X) and one commercial decontamination mean (Argos™) to permeate the pig skin, which could indicate a potential toxic side effect of mass casualty decontaminants. A method of static diffusion cells and UV spectrometry was used to evaluate the skin permeation. All tested agents did not permeate the skin in detectable amounts as 5% water solutions. In concentrated form, triton X and Argos™ did not permeate the skin whereas althosan MB 50% shown specific permeation rate of 6.134 μg.cm-1 in 24 hours.

Keywords: Tenside; diffusion cell; skin permeation; triton X; althosan MB; benzalkonium chloride; Argos™

Received: June 12, 2012; Revised: August 23, 2012; Published: September 7, 2012  Show citation

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Misík, J., Pavlíková, R., Cabal, J., Josse, D., & Kuča, K. (2012). IN VITRO SKIN PERMEATION OF DETERGENTS AND DETERGENT-BASED DECONTAMINATION MIXTURE. MMSL, 81(3), 96-99. doi: 10.31482/mmsl.2012.015
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