MMSL 2012, 81(4):164-170 | DOI: 10.31482/mmsl.2012.023

FROM THE RESEARCH OF CHOLINESTERASE REACTIVATORS TO THE EFFECTIVE THERAPY OF ORGANOPHOSPHATE/NERVE AGENT POISONINGOriginal article

Jiøí Bajgar1,2*, Jiøí Kassa ORCID...1
1 Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
2 Department of Radiology and Toxicology, Faculty of Health and Social Studies, University of South Bohemia, Ceske Budejovice, Czech Republic

OBJECTIVES: The aim of this study is to inform about different techniques used to improve treatment of nerve agents intoxication at the Department of Toxicology.

METHODS: Different methods are briefly mentioned and their importance for development of more effective reactivators is discussed.

RESULTS: Basic characterization of nerve agents and therapeutic drugs is necessary after literature survey. Usage of different techniques and properties of various reactivators are studied and, on this basis, the most effective ones are tested in details and proposed for practical use.

CONCLUSIONS: The results described in this study clearly demonstrate that for the development of new and more effective cholinesterase reactivators, a complex approach using different methodical attitudes is necessary.

Keywords: acetylcholinesterase; reactivators; methods; therapeutic efficacy; nerve agents

Received: August 23, 2012; Revised: September 19, 2012; Published: December 7, 2012  Show citation

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Bajgar, J., & Kassa, J. (2012). FROM THE RESEARCH OF CHOLINESTERASE REACTIVATORS TO THE EFFECTIVE THERAPY OF ORGANOPHOSPHATE/NERVE AGENT POISONING. MMSL, 81(4), 164-170. doi: 10.31482/mmsl.2012.023
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