MMSL, 2012 (vol. 81), issue 4
TOXIC ALCOHOLS: ALIPHATIC SATURATED ALCOHOLSReview article
Jiří Patočka, Kamil Kuča
MMSL 2012, 81(4):142-163 | DOI: 10.31482/mmsl.2012.022 
Toxic alcohols that clinicians commonly encounter are ethylene glycol, methanol, and isopropanol. Adults ingest these either for suicidal intent or to achieve inebriation, since these substances are readily available and cheaper than alcohol. Nevertheless, assorted alcohols are used very often in many applications and any alcohol can be toxic if ingested in large enough quantities. Toxic alcohols discussed here include all saturated aliphatic alcohols containing from 1 to 6 carbons in their molecules.
FROM THE RESEARCH OF CHOLINESTERASE REACTIVATORS TO THE EFFECTIVE THERAPY OF ORGANOPHOSPHATE/NERVE AGENT POISONINGOriginal article
Jiří Bajgar, Jiří Kassa
MMSL 2012, 81(4):164-170 | DOI: 10.31482/mmsl.2012.023
OBJECTIVES: The aim of this study is to inform about different techniques used to improve treatment of nerve agents intoxication at the Department of Toxicology.METHODS: Different methods are briefly mentioned and their importance for development of more effective reactivators is discussed.RESULTS: Basic characterization of nerve agents and therapeutic drugs is necessary after literature survey. Usage of different techniques and properties of various reactivators are studied and, on this basis, the most effective ones are tested in details and proposed for practical use.CONCLUSIONS: The results described in this study clearly demonstrate that for the...
ACUTE TOXICITY OF SURFACTANTS AND DETERGENT-BASED DECONTAMINANTS IN MICE AND RATSOriginal article
Jan Misík, Eva Vodáková, Růžena Pavlíkova, Jiří Cabal, Ladislav Novotný, Kamil Kuča
MMSL 2012, 81(4):171-176 | DOI: 10.31482/mmsl.2012.024
Detergent-based mixtures and pure surfactants used as decontaminants in mass casualty scenarios were investigated for their acute 24 h toxicity. Commercial detergents NeodekontTM, ArgosTM, DermogelTM, and FloraFreeTM were tested in male Wistar rats after percutaneous, peroral and intramuscular administration. Pure surfactants althosan MB, sodium alkylbenzene sulphonate, triton X, benzyl dimethyl dodecyl ammonium chloride, and N-dodecyl pyridinium bromide were investigated in male ICR mice. Estimated LD50 of surfactants varied from < 100 mg.kg-1 (i.m.) to more than 2000 mg.kg-1...
PHOSPHATIDYLINOSITOL-3-KINASE RELATED KINASES (PIKKS) IN RADIATION-INDUCED DNA DAMAGEReview article
Aleš Tichý, Kamila Ďurišová, Eva Novotná, Lenka Zárybnická, Jiřina Vávrová, Jaroslav Pejchal, Zuzana Šinkorová
MMSL 2012, 81(4):177-187 | DOI: 10.31482/mmsl.2012.025
This review describes a drug target for cancer therapy, family of phosphatidylinositol-3 kinase related kinases (PIKKs), and it gives a comprehensive review of recent information. Besides general information about phosphatidylinositol-3 kinase superfamily, it characterizes a DNA-damage response pathway since it is monitored by PIKKs.
METHANOL-INDUCED BLINDNESS TREATED BY ERYTHROPOIETIN; A RAY OF HOPE IN THE DARKEST OF CLOUDSLetter to the editor
Hossein Sanaei-Zadeh
MMSL 2012, 81(4):188-189 | DOI: 10.31482/mmsl.2012.026
It has previously been shown that in methanolinduced toxic optic neuropathy with absolute blindness, recovery is rare, and almost never happens fully (1, 2). In other words, we have shown that after general management of acute methanol intoxication, patients with methanolinduced blindness can be grouped into three categories; 1: patients who are blind at the time of discharge and partially recover within a maximum of 3-4 weeks; 2: patients who are blind at the time of discharge and gain no improvement in their vision; and 3: patients who are blind at the time of discharge, partially recover within a few days to approximately 1 month, and experience...
THE 12th CONFERENCE OF THE SOCIETY OF MILITARY PHYSICIANS, PHARMACISTS AND VETERINARIANS OF THE CZECH MEDICAL ASSOCIATION OF J.E. PURKINJE IN HRADEC KRÁLOVÉLetter to the editor
Leo Klein
MMSL 2012, 81(4):190-191
The main topics of the Conference were current issues in the Military Medical Service organization and management, progress in diagnostics and therapy in military general practitioners and in hospital facilities, scientific and research work in military healthcare, latest experience in foreign missions and in pre-deployment training. In total 34 oral presentations were delivered and 15 high-quality posters were displayed. The latest news related to formation and development of the ACR Military Medical Service contemporary concept, particularly in consideration of economic restrictions on public budget, and about the Czech Armed Forces reform, attracted...