MMSL 2013, 82(4):172-179 | DOI: 10.31482/mmsl.2013.027

THE POSSIBILITY OF IDENTIFYING SELECTED OPIOIDS BY SPECTRAL ANALYSISReview article

Romana Jelínková*, Emil Halámek, Zbyněk Kobliha
NBC Defence Institute of the University of Defence, Vyskov, CzechRepublic

The ability of the examined compounds to create ion pairs with the selected anionic dyes, allows their determination by the method of extraction spectrophotometry in the visible radiation. These ion pairs are extractable with an organic solvent immiscible with water. The procedure is based on protonisation of the studied compounds in acidic environment, and consequently their extraction in the form of associate with the anion of the acid dye into the organic phase, in this case in chloroform.Mentioned methods of analysis may be advantageously used for simple and express determination of fentanyl, alfentanil and remifentanil.

Keywords: Fentanyl; alfentanil; remifentanil; ion pairs; UV/VIS spectrophotometry; azo dyes

Received: April 29, 2013; Revised: August 13, 2013; Published: December 5, 2013  Show citation

ACS AIP APA ASA Harvard Chicago Chicago Notes IEEE ISO690 MLA NLM Turabian Vancouver
Jelínková, R., Halámek, E., & Kobliha, Z. (2013). THE POSSIBILITY OF IDENTIFYING SELECTED OPIOIDS BY SPECTRAL ANALYSIS. MMSL, 82(4), 172-179. doi: 10.31482/mmsl.2013.027
Share...
Download citation
  • BibTeX (.bib)
  • Bookends (.ris)
  • EasyBib (.ris)
  • EndNote (.enw)
  • EndNote 8 (.xml)
  • ISI WoS (.isi)
  • Medlars (.medlars)
  • Mendeley (.ris)
  • MODS (.xml)
  • Papers (.ris)
  • RefWorks (.txt)
  • RefManager (.ris)
  • RIS (.ris)
  • MS Word (.xml)
  • Zotero (.ris)
    • Open full article

    References

    1. STŘEDA, L.; PATOČKA, J. Neletální chemické zbraně a Úmluva o zákazu chemických zbraní. Vojenské zdravotnické listy, 2004. LXXIII, č. 5-6.
    2. WAX, P. M.; BECKER, C. E.; CURRY, S. C. Unexpected "gas" casualties in Moscow: a medical toxicology perspective. Annals of Emergency Medicine, 2003, 41, 700-705. Go to original source... Go to PubMed...
    3. Terrorists seize Moscow theatre, BBC News, 23 October, 2002. Available from: URL http://news.bbc.co.uk/2/hi/europe/2354753.stm
    4. RICHES R. J.; READ W. R.; BLACK M. R.; COOPER J. N.; TIMPERLEY M. C. Analysis of Clothing and Urine from Moscow Theatre Siege Casualties Reveals Carfentanil and Remifentanil Use. Journal of Analytical Toxicology, 2012, 36, 647-656. Go to original source... Go to PubMed...
    5. WANG. Q et all. Development od a Homogeneous Immunoassay for the Detection of fentanyl in urine. Forensic Science International. 2011, 206, 127-131. Go to original source... Go to PubMed...
    6. STRANO-ROSSI, S. Determination of Fentanyl, Metabolite and Analogs in Urine by GC/MS. Journal of Applied Toxicology. 2011, 31(7), 649-654. Doi: 10.1002/jat.1613 Go to original source... Go to PubMed...
    7. HALÁMEK, E.; KOBLIHA, Z. Investigation of the Conditions of Extraction of Ion-Associates of 3-Quinuclidinyl Benzilate with Acidic Dyes. Collection of Czechoslovak Chemical Communication, 1993, 58, 315-319. Go to original source...
    8. KOBLIHA, Z., HALÁMEK, E., SOUČEK, J. Skupinový test k určení aminických sloučenin. Patent ČSFR; 277616. 1992.
    9. LÜLLMANN, H.; MOHR, K.; WELHING, M. Farmakologie a toxikologie. 2. vyd. Praha: Grada Publishing, 2004. ISBN 80-247-0836-1.
    10. DEJMEK, L. Extrémně účinná narkotická analgetika - nový typ "imobilizačních" BCHL? Vojenské zdravotnické listy, 2004, 73(1), 27-36.
    11. TATEISHI, T.; WOOD, A. J. J.; GUENGERICH, F. P.; WOOD, M. Biotransformation of tritiated fentanyl in human liver microsomes. Biochemical Pharmacology, 1995, 50(11). 1921-1924. Go to original source... Go to PubMed...
    12. MATHEW, J. at al. Methods for the syntesis of Alfentanil, Remifentanil and Sufentanil. United States Patent No: US 7,208,604 B2. 2007.
    13. MEISTELMAN, C.; SAINT MAURICE, C.; LEPAUL, M. et al. A Comparison of Alfentanil Pharmacokinetics in Children and Adults. Anesthesiology, 1987, 66(1), 13-16. Go to original source... Go to PubMed...
    14. BILLARD, V.; SERVIN, F. S. Remifentanil and Other Opioids. Handbook of Experimental Pharmacology, 2008, 182, 283 - 311. ISSN 0171-2004. Go to original source... Go to PubMed...
    15. SINGLER, B. Modulation of remifentanil-induced postinfusion hyperalgesia by propofol. Anesthesia and analgesia, 2007, 104, (6), 1397-403. ISSN: 1526-7598. Go to original source... Go to PubMed...
    16. BORODKIN, F., V. Chemie organických barviv. 1. Vydání. Praha, SNTL. 1987.
    17. JANDERA, P. Atomová a molekulová spektroskopie se zaměřením na stopovou analýzu kontaminantů. 3. vyd. Pardubice: Univerzita Pardubice, 2011. ISBN 978-80-7395-392-8.
    18. ČŮTA, F. a kol. Instrumentální analýza. 1. vyd. Praha: SNTL, 1986.
    19. MELOUN, M.; MILITKÝ, J. Kompendium statistického zpracování dat. 2. vyd. Praha: Academia, 2006. ISBN 80-200-1396-2, 81(1), 1-24 (1987).

    Return to the content