MMSL 2014, 83(1):28-33 | DOI: 10.31482/mmsl.2014.005

THE CELL SURVIVAL FUNCTION OF JNKReview article

Qing-Hua Wu1,2,3, Zong-Hui Yuan2, Xiu-Juan Zhang4*
1 College of Life Science, Yangtze University, Jingzhou, Hubei, China
2 National Reference Laboratory of Veterinary Drug Residues (HZAU) and MAO Key Laboratory for Detection of Veterinary Drug Residues; MOA Laboratory of Risk Assessment for Quality and Safety of Livestock and Poultry Products, Huazhong Agricultural University, Wuhan, Hubei 430070, China
3 Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic
4 College of Horticulture & Gardening, Yangtze University, Jingzhou, Hubei, China

c-Jun N-terminal kinases (JNK) can be activated by multiple environmental stress, leading to varied and contradictory cellular response. JNK mediates cell apoptosis as well as cell survival and proliferation. JNK1 and JNK2 as the major members are able to perform similar and distinct biological functions. This review mainly discussed the mechanism of JNK cell survival function and the distinct roles of JNK1 and JNK2 in cell apoptosis and proliferation. Transient JNK activation may be important for mediating a survival response in TNF-treated cells and chronic JNK activation may contribute to apoptotic response. Other signal transduction pathways may also participate in its protective function. Abrogation of p38 MAPK pathway is assumed to induce pro-survival role. JNK suppresses apoptosis via phosphorylation of the pro-apoptotic Bcl-2 family protein BAD. Activated JNK inactivates suppressors of the apoptotic machinery, thereby "breaking the brake" on apoptosis.

Keywords: JNK; apoptosis; cell survival; JNK1; JNK2

Received: March 9, 2014; Revised: March 23, 2014; Published: April 7, 2014  Show citation

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Wu, Q., Yuan, Z., & Zhang, X. (2014). THE CELL SURVIVAL FUNCTION OF JNK. MMSL, 83(1), 28-33. doi: 10.31482/mmsl.2014.005
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