MMSL 2014, 83(2):46-51

INSTITUTE OF MOLECULAR PATHOLOGY, FMHS, UoD, HRADEC KRALOVE - TWENTY YEARS OF EXISTENCEReview article

Aleš Macela ORCID...*, Jiří Stulík ORCID...
Institute of Molecular Pathology, FMHS, UoD, 500 01 Hradec Kralove, Czech Republic

The Institute of Molecular Pathology was founded on May 1, 1994 as a scientific centre of the Purkyne Military Medical Academy. During the twenty years of its existence the Institute has gained reputation of a qualified research centre focused on infection biology, clinical proteomic studies and biodefense. The advanced proteomics combined with cellular and molecular biology techniques and broad international collaboration have enabled the Institute to educate Ph.D. students at the highest possible level. Meetings, workshops, and conferences organized by the Institute have been attended by recognized scientists. The twentieth anniversary of the Institute foundation is a good opportunity to recap the results of its work.

Keywords: Institute of Molecular Pathology; Proteomics; Francisella tularensis; Biodefense

Received: April 10, 2014; Revised: May 15, 2014; Published: June 2, 2014  Show citation

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Macela, A., & Stulík, J. (2014). INSTITUTE OF MOLECULAR PATHOLOGY, FMHS, UoD, HRADEC KRALOVE - TWENTY YEARS OF EXISTENCE. MMSL83(2), 46-51
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References

  1. Trebichavský I. Jak přišli lovci mikrobů do Orlických hor. (Czech) Private Archive. 2012, 1-14.
  2. Macela A, Stulik J, Hernychova L, Kroca M, Krocova Z, Kovarova H. The immune response against Francisella tularensis live vaccine strain in Lps(n) and Lps(d) mice. FEMS Immunol Med Microbiol. 1996, 13, 235-8. Go to original source... Go to PubMed...
  3. Hernychova L, Kovarova H, Macela A, Kroca M, Krocova Z, Stulik J. Early consequences of macrophage-Francisella tularensis interaction under the influence of different genetic background in mice. Immunol Lett. 1997, 57, 75-81. Go to original source... Go to PubMed...
  4. Kovárová H, Hernychová L, Hajdúch M, Sírová M, Macela A. Influence of the bcg locus on natural resistance to primary infection with the facultative intracellular bacterium Francisella tularensis in mice. Infect Immun. 2000, 68, 1480-4. Go to original source... Go to PubMed...
  5. Stulík J, Hernychová L, Macela A, Krocová Z, Kroca M. Production of stress-inducible form of heat-shock protein 70 in mouse peritoneal adherent cells after in vivo infection by Francisella tularensis. Folia Microbiol (Praha). 1999, 44, 306-10. Go to original source... Go to PubMed...
  6. Krocova Z, Härtlova A, Souckova D, Zivna L, Kroca M, Rudolf E, et al. Interaction of B cells with intracellular pathogen Francisella tularensis. Microb Pathog. 2008, 45, 79-85. Go to original source... Go to PubMed...
  7. Zivna L, Krocova Z, Härtlova A, Kubelkova K, Zakova J, Rudolf E, et al. Activation of B cell apoptotic pathways in the course of Francisella tularensis infection. Microb Pathog. 2010, 49, 226-36. Go to original source... Go to PubMed...
  8. Fabrik I, Härtlova A, Rehulka P, Stulik J. Serving the new masters - dendritic cells as hosts for stealth intracellular bacteria. Cell Microbiol. 2013, 15, 1473-83. Go to original source... Go to PubMed...
  9. Hrstka R, Stulík J, Vojtesek B. The role of MAPK signal pathways during Francisella tularensis LVS infection-induced apoptosis in murine macrophages. Microbes Infect. 2005, 7, 619-25. Go to original source... Go to PubMed...
  10. Hrstka R, Krocová Z, Cerný J, Vojtesek B, Macela A, Stulík J. Francisella tularensis strain LVS resides in MHC II-positive autophagic vacuoles in macrophages. Folia Microbiol (Praha). 2007, 52, 631-6. Go to original source... Go to PubMed...
  11. Härtlova A, Link M, Balounova J, Benesova M, Resch U, Straskova A, et al. Quantitative Proteomics Analysis of Macrophage-Derived Lipid Rafts Reveals Induction of Autophagy Pathway at the Early Time of Francisella tularensis LVS Infection. J Proteome Res. 2014, 13, 796-804. Go to original source... Go to PubMed...
  12. Pávková I, Brychta M, Strašková A, Schmidt M, Macela A, Stulík J. Comparative proteome profiling of host-pathogen interactions: insights into the adaptation mechanisms of Francisella tularensis in the host cell environment. Appl Microbiol Biotechnol. 2013, 97, 10103-15. Go to original source... Go to PubMed...
  13. Hernychová L, Stulík J, Halada P, Macela A, Kroca M, Johansson T, et al. Construction of a Francisella tularensis two-dimensional electrophoresis protein database. Proteomics 2001, 1, 508-15. Go to original source... Go to PubMed...
  14. Hubálek M, Hernychová L, Havlasová J, Kasalová I, Neubauerová V, Stulík J, et al. Towards proteome database of Francisella tularensis. J Chromatogr B Analyt Technol Biomed Life Sci. 2003, 787, 149-77. Go to original source... Go to PubMed...
  15. Balonova L, Hernychova L, Mann BF, Link M, Bilkova Z, Novotny MV, et al. Multimethodological approach to identification of glycoproteins from the proteome of Francisella tularensis, an intracellular microorganism. J Proteome Res. 2010, 9, 1995-2005. Go to original source... Go to PubMed...
  16. Konecna K, Hernychova L, Reichelova M, Lenco J, Klimentova J, Stulik J, et al. Comparative proteomic profiling of culture filtrate proteins of less and highly virulent Francisella tularensis strains. Proteomics. 2010, 10, 4501-11. Go to original source... Go to PubMed...
  17. Hubálek M, Hernychová L, Brychta M, Lenco J, Zechovská J, Stulík J. Comparative proteome analysis of cellular proteins extracted from highly virulent Francisella tularensis ssp. tularensis and less virulent F. tularensis ssp. holarctica and F. tularensis ssp. mediaasiatica. Proteomics. 2004, 4, 3048-60. Go to original source... Go to PubMed...
  18. Pávková I, Hubálek M, Zechovská J, Lenco J, Stulík J. Francisella tularensis live vaccine strain: proteomic analysis of membrane proteins enriched fraction. Proteomics. 2005, 5, 2460-7. Go to original source... Go to PubMed...
  19. Havlasová J, Hernychová L, Brychta M, Hubálek M, Lenco J, Larsson P, et al. Proteomic analysis of anti-Francisella tularensis LVS antibody response in murine model of tularemia. Proteomics. 2005, 5, 2090-103. Go to original source... Go to PubMed...
  20. Janovská S, Pávková I, Reichelová M, Hubáleka M, Stulík J, Macela A. Proteomic analysis of antibody response in a case of laboratory-acquired infection with Francisella tularensis subsp. tularensis. Folia Microbiol (Praha). 2007, 52, 194-8. Go to original source... Go to PubMed...
  21. Lenco J, Pavkova I, Hubalek M, Stulik J. Insights into the oxidative stress response in Francisella tularensis LVS and its mutant DeltaiglC1+2 by proteomics analysis. FEMS Microbiol Lett. 2005, 246, 47-54. Go to original source... Go to PubMed...
  22. Lenco J, Hubálek M, Larsson P, Fucíková A, Brychta M, Macela A, et al. Proteomics analysis of the Francisella tularensis LVS response to iron restriction: induction of the F. tularensis pathogenicity island proteins IglABC. FEMS Microbiol Lett. 2007, 269, 11-21. Go to PubMed...
  23. Larsson P, Oyston PCF, Chain P, Chu MC, Duffield M, Fuxelius H-H, et al. The complete genome sequence of Francisella tularensis, the causative agent of tularemia. Nat Genet. 2005, 37, 153-9. Go to original source... Go to PubMed...
  24. Meibom KL, Dubail I, Dupuis M, Barel M, Lenco J, Stulik J, et al. The heat-shock protein ClpB of Francisella tularensis is involved in stress tolerance and is required for multiplication in target organs of infected mice. Mol Microbiol. 2008, 67, 1384-401. Go to original source... Go to PubMed...
  25. Dieppedale J, Sobral D, Dupuis M, Dubail I, Klimentova J, Stulik J, et al. Identification of a putative chaperone involved in stress resistance and virulence in Francisella tularensis. Infect Immun. 2011, 79, 1428-39. Go to original source... Go to PubMed...
  26. Straskova A, Cerveny L, Spidlova P, Dankova V, Belcic D, Santic M, et al. Deletion of IglH in virulent Francisella tularensis subsp. holarctica FSC200 strain results in attenuation and provides protection against the challenge with the parental strain. Microbes Infect. 2012, 14, 177-87. Go to original source... Go to PubMed...
  27. Schmidt M, Klimentova J, Rehulka P, Straskova A, Spidlova P, Szotakova B, et al. Francisella tularensis subsp. holarctica DsbA homologue: a thioredoxin-like protein with chaperone function. Microbiology (Reading, Engl). 2013, 159, 2364-74. Go to original source... Go to PubMed...
  28. Stulík J, Bures J, Jandík P, Langr F, Kovárová H, Macela A. The different expression of proteins recognized by monoclonal anti-heat shock protein 70 (hsp70) antibody in human colonic diseases. Electrophoresis. 1997, 18, 625-8. Go to PubMed...
  29. Stulík J, Kovárová H, Macela A, Bures J, Jandík P, Langr F, et al. Overexpression of calcium-binding protein calgranulin B in colonic mucosal diseases. Clin Chim Acta. 1997, 265, 41-55. Go to original source... Go to PubMed...
  30. Stulík J, Osterreicher J, Koupilová K, Knízek, Macela A, Bures J, et al. The analysis of S100A9 and S100A8 expression in matched sets of macroscopically normal colon mucosa and colorectal carcinoma: the S100A9 and S100A8 positive cells underlie and invade tumor mass. Electrophoresis. 1999, 20, 1047-54. Go to original source... Go to PubMed...
  31. Stulík J, Koupilova K, Osterreicher J, Knízek J, Macela A, Bures J, et al. Protein abundance alterations in matched sets of macroscopically normal colon mucosa and colorectal carcinoma. Electrophoresis. 1999, 20, 3638-46. Go to original source... Go to PubMed...
  32. Jungblut PR, Zimny-Arndt U, Zeindl-Eberhart E, Stulik J, Koupilova K, Pleissner KP, et al. Proteomics in human disease: cancer, heart and infectious diseases. Electrophoresis. 1999, 20, 2100-10. Go to original source...
  33. Tambor V, Fucíková A, Lenco J, Kacerovský M, Rehácek V, Stulík J, et al. Application of proteomics in biomarker discovery: a primer for the clinician. Physiol Res. 2010, 59, 471-97. Go to original source...
  34. Pudil R, Vasatová M, Lenco J, Tichý M, Rehácek V, Fucíková A, et al. Plasma glycogen phosphorylase BB is associated with pulmonary artery wedge pressure and left ventricle mass index in patients with hypertrophic cardiomyopathy. Clin Chem Lab Med. 2010, 48, 1193-5. Go to original source... Go to PubMed...
  35. Kacerovsky M, Drahosova M, Hornychova H, Tambor V, Flidrova E, Musilova I, et al. Umbilical cord blood concentration of soluble scavenger receptor for hemoglobin, but not pentraxin 3, is of value for the early postpartum identification of the presence of histological chorioamnionitis. J Matern Fetal Neonatal Med. 2011, 24, 1228-34. Go to original source... Go to PubMed...
  36. Kacerovsky M, Tambor V, Vajrychová M, Lenco J, Hornychova H, Musilova I, et al. Amniotic fluid myeloperoxidase in pregnancies complicated by preterm prelabor rupture of membranes. J Matern Fetal Neonatal Med. 2013, 26, 463-8. Go to original source... Go to PubMed...
  37. Tambor V, Kacerovsky M, Andrys C, Musilova I, Hornychova H, Pliskova L, et al. Amniotic fluid cathelicidin in PPROM pregnancies: from proteomic discovery to assessing its potential in inflammatory complications diagnosis. PLoS ONE. 2012, 7, e41164. Go to original source... Go to PubMed...
  38. Tambor V, Kacerovsky M, Lenco J, Bhat G, Menon R. Proteomics and bioinformatics analysis reveal underlying pathways of infection associated histologic chorioamnionitis in pPROM. Placenta. 2013, 34, 155-61. Go to original source... Go to PubMed...
  39. Kubelkova K, Krocova Z, Balonova L, Pejchal J, Stulik J, Macela A. Specific antibodies protect gamma-irradiated mice against Francisella tularensis infection. Microb Pathog. 2012, 53, 259-68. Go to original source... Go to PubMed...