MMSL, 2014 (vol. 83), issue 2
INSTITUTE OF MOLECULAR PATHOLOGY, FMHS, UoD, HRADEC KRALOVE - TWENTY YEARS OF EXISTENCEReview article
Aleš Macela, Jiří Stulík
MMSL 2014, 83(2):46-51 
The Institute of Molecular Pathology was founded on May 1, 1994 as a scientific centre of the Purkyne Military Medical Academy. During the twenty years of its existence the Institute has gained reputation of a qualified research centre focused on infection biology, clinical proteomic studies and biodefense. The advanced proteomics combined with cellular and molecular biology techniques and broad international collaboration have enabled the Institute to educate Ph.D. students at the highest possible level. Meetings, workshops, and conferences organized by the Institute have been attended by recognized scientists. The twentieth anniversary of the Institute...
K-OXIME (K-27): PHOSPHYLATION-INDUCED CHANGES IN LOGPOriginal article
Georg A Petroianu, Gagani Athauda, Ferenc Darvas, Huba Kalasz, Dietrich E Lorke
MMSL 2014, 83(2):52-58 | DOI: 10.31482/mmsl.2014.009
Organophosphorus compounds (organophosphates and organophosphonates) exert their toxicity by phosphylating (i.e. either phosphorylating or phosphonylating) the serine hydroxyl group of the enzyme acetylcholinesterase (AChE) in its active center, thereby inhibiting this enzyme, which inactivates the neurotransmitter acetylcholine (ACh). This results in an accumulation of ACh and an "endogenous ACh poisoning".Oximes, which can reactivate the inhibited enzyme by dephosphylation, are used in the therapy of organophosphorus compound poisoning. During the reactivation process, oximes become themselves phosphylated. Many of these phosphylated oximes are...
BENEFITS OF CLOUD COMPUTING IN BIOMEDICINEReview article
Petra Marešová, Vladimír Soběslav, Kamil Kuča
MMSL 2014, 83(2):59-66 | DOI: 10.31482/mmsl.2014.010
Currently, Biomedicine is characterised by a growing need for processing large amounts of data in real time. This leads to new requirements for information and communication technologies (ICT). Cloud computing offers a solution to these requirements and provides a lot of advantages such as cost savings, elasticity and scalability of using ICT.The aim of this paper is to explore the concept of cloud computing. Firstly, the forms of cloud computing are described. Secondly, the potential benefits and limitations of Biomedicine technology are discussed. Finally, the current (present) situation of using this technology in Biomedicine in the Czech Republic...
THE USE OF IMMUNOENZYMATIC METHOD FOR DETECTION OF ANTIBODIES AGAINST ZOONOTIC DISEASES IN CZECH SOLDIERS RETURNING FROM AFGHANISTANOriginal article
Petra Straková, Ivo Rudolf, Oto Pavliš, Zdeněk Hubálek
MMSL 2014, 83(2):67-72 | DOI: 10.31482/mmsl.2014.011
In this work, we focused on detection of IgG antibodies in the blood sera from Czech soldiers returning from Afghanistan against selected zoonotic diseases by commercially available ELISA kits. Samples were tested for the presence of antibodies against Brucella abortus, Coxiella burnetii, Leptospira spp., complex of Rickettsia conorii, Leishmania infantum, hantaviruses and hepatitis E virus. Except for L. infantum (all persons were negative), we found following seroreactivity rate: 10 % in B. abortus, 11 % in C. burnetii, 20 % in Leptospira spp., 10 % in R. conorii and 4 % in both...
IRRITANT COMPOUNDS: RESPIRATORY IRRITANT GASESReview article
Jiří Patočka, Kamil Kuča
MMSL 2014, 83(2):73-82 | DOI: 10.31482/mmsl.2014.012
Respiratory irritants are substances which can cause inflammation or other adverse reactions in the respiratory system (lungs, nose, mouth, larynx and trachea) after being inhaled. Depending on the type and amount of irritant gas inhaled, victims can experience symptoms ranging from minor respiratory discomfort to acute airway and lung injury and even death. The lungs are susceptible to many airborne irritants. A common response cascade to a variety of irritant gases includes inflammation, edema and epithelial sloughing which, left untreated, can result in scar formation and pulmonary and airway remodeling. There are hundreds of substances that can...
THE 90th BIRTHDAY OF VLADIMÍR MĚRKALetter to the editor
Leo Klein, Josef Fusek
MMSL 2014, 83(2):83-84
This May, Colonel (Retd.) Associate Professor RNDr. et PhMr. Vladimír Měrka, CSc., celebrates his 90th birthday.Our honouree is well known to readers of Military Medical Science Letters as, over the years, he has published many scientific papers and was the diligent author of countless studies. Due to his lifelong work and the results of pedagogical and scientific endeavour, Professor Měrka belongs among the most important personalities in the field of military medicine...
THE 10th CONGRESS OF THE CZECH VACCINATION SOCIETY, X. HRADEC VACCINATION DAYSAnnouncement
Roman Chlíbek
MMSL 2014, 83(2):85
MAIN TOPICS: News in vaccination 2014, Invasive bacterial diseases, Rotavirus gastroenteritis, Human papillomavirus diseases, Therapeutic cancer vaccines, Selected case reports in vaccination, Controversies in vaccination, Current problems of vaccination in selected diseases, Vaccination against exanthema diseases.
17th ANNUAL MEETING OF ESCV, PRAGUE 2014Announcement
Vlasta Štěpánová
MMSL 2014, 83(2):86
MAIN TOPICS: Influenza and new respiratory viral agents, Viral emerging infections, Viral congenital and neonatal infections, Viral blood born infections, Anthropozoonoses of viral origin, Viral gastroenteritis, Viruses and immunosuppressed host, Viral pathogenesis and immunity, Viral diagnosis, Viruses and oncogenesis, New antiviral agents, Strategies and progress in viral vaccines, Molecular epidemiology, Quality assurance in virology laboratory.
NEW BOOK: PROBLEMS OF TOXICLOGYLetter to the editor
Christophor Dishovsky
MMSL 2014, 83(2):87
The Bulgarian Toxicological Society edited a book "Problems of Toxiclogy". This book includes reports which were presented at the Fourth National Congress of Clinical Toxicology with International Participation and Annual Meeting of Bulgarian Toxicological Society, which were held in Sofia, Military Medical Academy, Bulgaria, from 7th to 8th November, 2013...
TOXCON 2014Announcement
Mojmír Mach
MMSL 2014, 83(2):88
The main topics of the upcoming Conference will be environmental and industrial toxicology, food toxicology, experimental and clinical toxicology, and important problem of the contemporary world - bioterrorism and military toxicology.