MMSL 2015, 84(3):104-114 | DOI: 10.31482/mmsl.2015.012

DEOXYNIVALENOL, A TRICHOTHECENE MYCOTOXIN: REVIEW OF ITS MASKED FORM, CONTAMINATION IN CEREAL-BASED FEED, AND MASS SPECTROMETRY ANALYTICAL METHODSReview article

Xiujuan Zhang1, Deyu Huang4, Dan Wan5, Qinghua Wu2,3*
1 College of Horticulture and Garden, Yangtze University, Jingzhou 434025, Hubei, China
2 College of Life Science, Yangtze University, Jingzhou 434025, Hubei, China
3 Center for Basic and Applied Research, Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove, Czech Republic
4 National Reference Laboratory of Veterinary Drug Residues (HZAU), Huazhong Agricultural University, Wuhan, Hubei 430070, China
5 Hunan Engineering and Research Center of Animal and Poultry Science, Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, China

Deoxynivalenol (DON) is a trichothecene mycotoxin regularly occurring in cereals. It is toxic to humans and inhibits DNA, RNA and protein synthesis. Moreover, its conjugated products, called masked mycotoxins, including DON-3-glucoside (DON-3G), is another "emerging" food safety issue in recent years. In this review, we first discussed the nature of contamination of masked DON in cereal-based food and feed; moreover, the new reported masked DON is summarized and we also focused on its toxicity and digestion in human and animal bodies. In addition, the contamination of DON in cereal-based feed in different countries was summarized and some regular patterns of DON occurrence are suggested. Finally, the LC-MS methods for the determination of DON and masked DON in food, feed and animal fluids were compared. This review will provide further information for DON and masked DON contamination and shed some light on the mycotoxin control strategies.

Keywords: deoxynivalenol; DON; masked mycotoxin; DON-3-glucoside; contamination; food safety

Received: May 11, 2015; Revised: May 17, 2015; Published: September 4, 2015  Show citation

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Zhang, X., Huang, D., Wan, D., & Wu, Q. (2015). DEOXYNIVALENOL, A TRICHOTHECENE MYCOTOXIN: REVIEW OF ITS MASKED FORM, CONTAMINATION IN CEREAL-BASED FEED, AND MASS SPECTROMETRY ANALYTICAL METHODS. MMSL, 84(3), 104-114. doi: 10.31482/mmsl.2015.012
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