MMSL, 2015 (vol. 84), issue 3
ACID DISSOCIATION CONSTANTS AND MOLECULAR DESCRIPTORS OF SOME XYLENE LINKED BISPYRIDINIUM OXIMESOriginal article
Namrata Singh, Ondřej Soukup, Rafael Doležal, Zdeněk Fišar, Bhanushree Gupta, Kallol K. Ghosh, Kamil Kuča
MMSL 2015, 84(3):94-103 | DOI: 10.31482/mmsl.2015.011 
The present article is aimed at determination of acid dissociation constants (pKa), lipophilicity (logP) and hydrogen bond acceptor (HBA) and donor (HBD) counts of some novel xylene-linked bispyridiniumoxime based AChE reactivators. The choice was supported by their use in the therapy of acute intoxication with organophosphorus AChE inhibitors. UV-Vis spectrophotometry has been used to measure experimental pKa values at 27°C, while software Marvin Sketch (chemaxon) has been used to estimate structure based computational pKa, logP values and hydrogen bonding parameters. The results...
DEOXYNIVALENOL, A TRICHOTHECENE MYCOTOXIN: REVIEW OF ITS MASKED FORM, CONTAMINATION IN CEREAL-BASED FEED, AND MASS SPECTROMETRY ANALYTICAL METHODSReview article
Xiujuan Zhang, Deyu Huang, Dan Wan, Qinghua Wu
MMSL 2015, 84(3):104-114 | DOI: 10.31482/mmsl.2015.012
Deoxynivalenol (DON) is a trichothecene mycotoxin regularly occurring in cereals. It is toxic to humans and inhibits DNA, RNA and protein synthesis. Moreover, its conjugated products, called masked mycotoxins, including DON-3-glucoside (DON-3G), is another "emerging" food safety issue in recent years. In this review, we first discussed the nature of contamination of masked DON in cereal-based food and feed; moreover, the new reported masked DON is summarized and we also focused on its toxicity and digestion in human and animal bodies. In addition, the contamination of DON in cereal-based feed in different countries was summarized and some regular patterns...
AGENTS FOR DEFENSE AGAINST CHEMICAL WARFARE: REACTIVATORS OF ACETYLCHOLINESTERASE INHIBITED WITH NEUROTOXIC ORGANOPHOSPHORUS COMPOUNDSReview article
Petronilho E. C., Figueroa-Villar J. D.
MMSL 2015, 84(3):115-127 | DOI: 10.31482/mmsl.2015.013
The chemical warfare agents and neurotoxic agents are an important threat to people all over the world, and require special attention because they are highly dangerous. Most of these agents are neurotoxic organophosphorus compounds (OP), which inhibit the enzyme acetylcholinesterase (AChE), which is responsible for controlling the transmission of nerve impulses. To be inhibited by these compounds, AChE can sometimes be reactivated using cationic oximes, which are the most used substances for this reactivation. Until today there have not been discovered agents for complete treatment of poisoning by all OPs. For this reason, the treatment of intoxicated...
IRRITANT COMPOUNDS: MILITARY RESPIRATORY IRRITANTS. PART I. LACRIMATORSReview article
Jiří Patočka, Kamil Kuča
MMSL 2015, 84(3):128-139 | DOI: 10.31482/mmsl.2015.014
World War I was a conflict where chemical warfare was first used on a massive scale. The earliest chemical attack occurred on the Western Front in October 1914 in Neuve Chapelle, but its effects were so minimal that the Allies learned about it only after the war from German documents. The attack in the Bolimow area, carried out by the Germans against the Russian army with artillery shells containing gas T (xylyl and benzyl bromides), was therefore the first attack on a massive scale recorded on the victim side. The attack, which occurred after it, made it possible to obtain some tactical success, but without a strategic breakthrough. Some of the later...
WAR INJURIES FROM PAST TO PRESENT. (EDS.) V. SMRČKA, V. MÁDLOVÁ, KAROLINUM PRESS, PRAGUE,1st EDITION, 2014, 178 PAGES, ISBN 978-80-246-2290-3.Book review
Miroslav Ryska
MMSL 2015, 84(3):140-141
The editors V. Smrčka and V. Mádlová prepared excellent proceedings of the Symposium "War injuries from past to present" held in Prague, on 5th March, 2011. It was published under the same title by the Karolinum Press (the publishing house of the Charles University, http://cupress.cuni.cz) in 2014.All the 12 papers describe the history of war injuries from approx. 3 500 to 2 000 BC to the present. Earlier conflicts did not have the character of organized violence between states and were not a continuation of policy which is, as the Prussian war theorist Carl von Clausewitz puts it, a definition of war. The history of war injuries is closely...
S. WILLIAM A. GUNN: DICTIONARY OF DISASTER MEDICINE AND HUMANITARIAN RELIEF (SECOND EDITION)Book review
Leo Klein
MMSL 2015, 84(3):142-143
Mass disasters, whether caused by natural, industrial or other man-made events, require rapid mitigation of the resultant consequences, for which equally rapid, simple and proper communication is an essential prerequisite for multidisciplinary rescue teams from various fields. Such communication is the only means by which lives can be saved and further damages prevented. In today's globalized world, wherein international co-operation in cases of mass disaster has become quite typical and necessary, the issue of inter-communication and understanding among teams has become all the more urgent. This also applies...
15th CONFERENCE ON MILITARY MEDICINEAnnouncement
Leo Klein
MMSL 2015, 84(3):144
Main topic: Military Health, Care and Support, Results of Medical/Surgical Treatment Procedures and Research, Varia, Poster Section.