The 8^th Singapore International Symposium for Protection Against Toxic Substances (SISPAT) is a technical forum that aims to share the latest knowledge and technology with regards to defence against unconventional threats amongst scientists and operations managers (military and public health) from the academia, government and other relevant industries. Asymmetrical threats posed by the use of unconventional agents transcend international boundaries and is constantly evolving to circumvent existing defence measures. Henceforth, defence measures against CBRN threats must leverage on bilateral and multi-lateral cooperation to remain effective. The theme for the 8th SISPAT, "Staying One Step Ahead of Evolving CBRNe Threats Through International Cooperation", reinforces the importance of continuing this tradition of information sharing, scientific exchange and close-knit interactions between international communities to counter such asymmetric threats.The Symposium will be held in conjunction with the 24^th edition of NCT CBRNe Asia and the 25^th edition of NCT eXplosive Asia.