MMSL, 2014 (vol. 83), issue 4
PORTER'S FIVE FORCES ON MEDICAL DEVICE INDUSTRY IN EUROPEReview article
Petra Marešová, Kamil Kuča
MMSL 2014, 83(4):134-144 | DOI: 10.31482/mmsl.2014.024 
Healthcare is an industry that has a very strong position in economies and a relatively high share of GDP. It also includes the medical device industry. The aim of this paper is to analyse the potential of the market for medical devices in Europe. The starting point is the analysis of the external environment, describing the selected macroeconomic variables affecting aggregate demand and therefore the medical device industry in selected countries. The tool for strategic analysis of the European market is Porter's Five Forces model, where initial information is obtained from the analysis of economic indicators of the given industry, analysis of world...
VIDEO-ASSISTED AND CT NAVIGATED REPOSITION OF AN ORBITAL BLOW-OUT FRACTUREOriginal article
Daniel Kovář, Zdeněk Voldřich, Pavel Voska, Jan Lešták, Eva Drahokoupilová
MMSL 2014, 83(4):145-150 | DOI: 10.31482/mmsl.2014.025
One possible use of CT navigated surgery in Otorinolaryngology includes traumatology of the facial skeleton.CT navigation enables a surgeon to assess the range and quality of reposition and fixation of a fracture, in our case the fracture of the orbital floor, using a navigated tube. We proceed from pre-operative CT of the paranasal sinuses images to navigation with 1,5-2,0 mm incisions and subsequent registration. Formerly, we used mainly transantral approach at our department, while currently we prefer subciliar approach with the use of absorbable materials (PDS or PMR splint).We use a rigid endoscope for infraorbital nerve decompression and delicate...
IRRITANT COMPOUNDS: ALDEHYDESReview article
Jiří Patočka, Kamil Kuča
MMSL 2014, 83(4):151-164 | DOI: 10.31482/mmsl.2014.026
Many aldehydes are respiratory irritants which can cause inflammation or other adverse reactions in the respiratory system after being inhaled. Depending on the type and amount of irritant compound inhaled, victims can exhibit symptoms ranging from minor respiratory discomfort to acute airway and lung injury and even death. The lungs are susceptible to many airborne irritants. There are hundreds of substances that can pollute air and harm lungs. Aldehydes are just one type of airborne pollutants that can adversely affect lungs. Some of these agents may be directly toxic. They are also strong irritants for the skin, eyes, and nasal passages. The vapor...
CHEMICAL WARFARE: PERSPECTIVES ON REACTIVATING THE ENZYME ACETYLCHOLINESTERASE INHIBITED BY ORGANOPHOSPHATESOriginal article
Juliana de O. S. Giacoppo, Willian E. A. de Lima, Kamil Kuča, Elaine F. F. da Cunha, Tanos C. C. França, Teodorico de C. Ramalho
MMSL 2014, 83(4):165-177 | DOI: 10.31482/mmsl.2014.027
It is known that nerve agents are potent inhibitors of acetylcholinesterase (AChE), the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine and, thus, transmission of nerve impulses. The process of AChE inhibition by nerve agents can be reversed by a nucleophile able to dephosphorylate the enzyme. In this sense, oximes exhibit this characteristic and are able to remove the neurotoxic and reactivate AChE. Here, we review experimental and theoretical results involving docking and quantum mechanical-molecular mechanics hybrid methods (QM/MM), using Molegro® and Spartan® softwares to analyze the interaction...
POLYMER THERAPEUTICS FOR TREATMENT OF VIRAL INFECTIONS SUCH AS EBOLA - HOW TO TEACH NEW TRICKS TO AN OLD DOG? A HYPOTHESIS.Short communication
Martin Hrubý
MMSL 2014, 83(4):178-182 | DOI: 10.31482/mmsl.2014.028
Polymer drug delivery systems were during last few decades proven to be efficient potential therapeutics for cancer treatment, especilly for the treatment of solid tumors, where they may take advantage of the Enhanced Permeability and Retention (EPR) effect for tumor-specific passive accumulation. Controlled release of anticancer drugs in cancer cells may be triggered by. e.g., cathepsin B activation after endocytosis. Endosomal proteases, especially cathepsins B and L, are known to be one of the key factors influencing some viral infections. For instance Ebola virus requires partial proteolysis of its surface glycoprotein for efficient endosome escape...
IGOR LINHART: TOXICOLOGY. INTERACTIONS OF NOXIOUS SUBSTANCES WITH LIVING ORGANISMS, THEIR MECHANISMS, MANIFESTATIONS AND EFFECTS. 2nd AMENDED AND SUPPLEMENTED EDITION. UNIVERSITY OF CHEMICAL TECHNOLOGY IN PRAGUE, 2014, 412P. ISBN 978-80-7080-877-L.Book review
Jiří Patočka
MMSL 2014, 83(4):183
The publishing house of the University of Chemical Technology in Prague published in a short time (first edition in 2012) amended and supplemented second edition of the Toxicology textbook. A chapter newly included in the second edition discusses the toxicity of some common chemical reagents and solvents and the risks to health and the environment which is or may be associated with work in chemical laboratories. The author of the textbook is assoc. prof. Ing. Igor Linhart, Ph.D., one of the prominent Czech...