VZL 2005, 74(5):172-174

Azaspiracid - a New Biotoxin

Vratislav Hrdina, Jiří Patočka ORCID...1, Vladimír Měrka2, Radomír Hrdina3
1 Jihočeská univerzita, Zdravotně sociální fakulta, České Budějovice
2 Univerzita obrany, Fakulta vojenského zdravotnictví v Hradci Králové
3 Univerzita Karlova v Praze, Farmaceutická fakulta v Hradci Králové

Azaspiracidy (AZA) představují nové zástupce mořských fykotoxinů nalezených v roce 1995 na pobřeží Irska. V listopadu 1995 tam onemocnělo nejméně osm osob po konzumaci slávek jedlých (Mytilus edulis). Z masa těchto mlžů bylo později izolováno pět strukturně podobných látek: azaspiracidy AZA-1 až AZA-5 a později ještě také AZA-6 až AZA-11. AZA se liší od všech až dosud známých mořských toxinů. Ke klinickým projevům AZA patří poruchy zažívacího ústrojí, jater a slinivky, ale v pokusech na myších rovněž svalová paralýza, tedy i neurotoxické účinky. Navzdory značnému významu AZA pro lidské zdraví zůstává mechanismus jejich toxického účinku nejasný. V předkládané práci podávají autoři základní informace o chemické struktuře a nejdůležitějších projevech intoxikace těmito látkami.

Keywords: Mořský toxin; Fykotoxin; Azaspiracid

Azaspiracids (AZAs) represent new members of phycotoxins discovered on the Irish coast in 1995. In November 1995, at least eight people became ill after eating mussels (Mytilus edulis). From the meat of these mussels five structurally similar compounds: azaspiracids AZA-1 to AZA-5 and afterwards also AZA-6 to AZA-11 were isolated. Azaspiracids differ from any of the previously known marine toxins. AZAs cause severe disturbances of the intestinal tract, liver and pancreas. A progressive muscular paralysis, i.e. neurotoxic effects, could be proved by the mouse bioassay. In spite of significant threat to human health the mechanism of AZAs toxic effects remain still unclear. Authors present fundamental information concerning a chemical structure and the most important intoxication syndromes caused by AZAs.

Keywords: Marine toxin; Fycotoxin; Azaspiracid

Received: November 2, 2005; Published: December 1, 2005  Show citation

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Hrdina, V., Patočka, J., Měrka, V., & Hrdina, R. (2005). Azaspiracid - a New Biotoxin. Vojenské Zdravotnické Listy, 74(5-6), 172-174
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