MMSL 2011, 80(3):118-128 | DOI: 10.31482/mmsl.2011.018

THE DISULFIDE BOND FORMATION AND ITS RELATIONSHIP TO BACTERIAL PATHOGENICITY OF THREE IMPORTANT GRAM-NEGATIVE BACTERIAReview article

Iva Šenitková ORCID...1*, Petra Špidlová ORCID...1, Lenka Hernychová1,2, Jiří Stulík ORCID...1
1 Institute of Molecular Pathology, Faculty of Military Health Sciences, University of Defence, Hradec Králové, Czech Republic
2 Masaryk Memorial Cancer Institute, Brno, Czech Republic

Disulfide bond formation is necessary for a correct folding and a proper function of many secreted proteins. We know that many of these proteins are involved in bacterial virulence and pathogenesis. The best known pathways of disulfide bond formation and isomerization belong to Escherichia coli (E. coli). This Gram-negative bacterium is usually used as a model organism. This review is aimed initially at introduction to E. coli oxido-reductase enzymatic system. The next part is interested in proteins resembling these from E. coli and their relation to virulence and pathogenesis. We have choosen three important Gram-negative pathogens, Neisseria meningitidis (N. meningitidis), Yersinia pestis (Y. pestis) and Francisella tularensis (F. tularensis), because of their high virulence, infectivity, ability to cause severe infections and absence of appropriate vaccines.

Keywords: Disulfide bond formation; DsbA; DsbB; DsbC; DsbD; DsbE; CcmG; Neisseria meningitidis; Yersinia pestis; Francisella tularensis

Received: June 27, 2011; Revised: August 24, 2011; Published: September 9, 2011  Show citation

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Šenitková, I., Špidlová, P., Hernychová, L., & Stulík, J. (2011). THE DISULFIDE BOND FORMATION AND ITS RELATIONSHIP TO BACTERIAL PATHOGENICITY OF THREE IMPORTANT GRAM-NEGATIVE BACTERIA. MMSL, 80(3), 118-128. doi: 10.31482/mmsl.2011.018
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