MMSL 2017, 86(1):32-41 | DOI: 10.31482/mmsl.2017.005

BRAZILIAN PEPPER TREE: REVIEW OF PHARMACOLOGYReview article

Jiří Patočka ORCID...1,2*, Joyce Diz de Almeida3
1 Institute of Radiology, Toxicology and Civil Protection, Faculty of Health and Social Studies, University of South Bohemia České Budějovice, České Budějovice, Czech Republic
2 Biomedical Research Centre, University Hospital, Hradec Kralove, Czech Republic
3 Military Institute of Engineering, Rio de Janeiro, Brazil

Brazilian pepper tree (Schinus terebinthifolius Raddi) from the Anacardiaceae family is native to Central and South America. In folk medicine, S. terebinthifolius has been used as a remedy for ulcers, respiratory problems, wounds, rheumatism, gout, diarrhea, skin ailments and arthritis, as well as to treat tumors and leprosy. The Brazilian pepper tree has various biological properties and it is a source of many bioactive compounds. Several classes of compounds can be found in extracts obtained from these plants, such as terpenes and flavonoids. Essential oils obtained by steam distillation or extraction by solvents from berries or leafs is rich in monoterpenes and shows interesting antioxidant activity. It has displayed good-to-very strong in vitro antifungal actions against numerous fungi, as well as Candida. The essential oil and leaves have demonstrated in vitro antibacterial activity against numerous bacterial strains.

Keywords: Brazilian pepper tree; Schinus terebinthifolius; ethnobotanics; traditional medicine; pharmacology; toxicology

Received: December 28, 2016; Revised: February 1, 2017; Published: March 10, 2017  Show citation

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Patočka, J., & de Almeida, J.D. (2017). BRAZILIAN PEPPER TREE: REVIEW OF PHARMACOLOGY. MMSL86(1), 32-41. doi: 10.31482/mmsl.2017.005
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References

  1. Barbosa LCA, Demuner AJ, Clemente AD, Paula VFD, Ismail F. Seasonal variation in the composition of volatile oils from Schinus terebinthifolius Raddi. Química Nova, 2007, 30(8), 1959-1965. Go to original source...
  2. Barbieri DS, Tonial F, Lopez PV, Maia BHS, Santos GD, Ribas MO, Glienke C, Vicente VA. Antiadherent activity of Schinus terebinthifolius and Croton urucurana extracts on in vitro biofilm formation of Candida albicans and Streptococcus mutans. Arch Oral Biol. 2014, 59(9), 887-896. Go to original source... Go to PubMed...
  3. Barkley FA. Schinus L. Brittonia 1944, 5, 160-198. Go to original source...
  4. Bendaoud H, Romdhane M, Souchard JP, Cazaux S, Bouajila J. Chemical composition and anticancer and antioxidant activities of Schinus molle L. and Schinus terebinthifolius Raddi berries essential oils. J Food Sci. 2010, 75(6), 466-472. Go to original source... Go to PubMed...
  5. Benzi V, Stefanazzi N, Ferrero AA. Biological activity of essential oils from leaves and fruits of pepper tree (Schinus molle L.) to control rice weevil (Sitophilus oryzae L). Chil J Agric Res. 2009, 69(2), 154-159. Go to original source...
  6. Borio EBL, Cecy C, Yasumoto Y. Pharmacognostic study of the bark of Schinus terebinthifolius Raddi (Anacardiaceae). Cienc Cult (São Paulo), 1973, 25(2), 631-634.
  7. Branco Neto ML, Ribas Filho JM, Malafaia O, et al. [Evaluation of hydroalcoholic extract of Aroeira (Shinus Terebinthifolius Raddi) in the healing process of wound skin in rats]. Acta Cir Bras. 2006, 21 Suppl 2, 17-22. Portuguese. Go to original source... Go to PubMed...
  8. Campelo J, Marsaioli AJ. Triterpenes of Schinus terebinthifolius. Phytochemistry. 1974, 13, 659-660. Go to original source...
  9. Carlini EA, Duarte-Almeida JM, Tabach R. Assessment of the Toxicity of the Brazilian Pepper Trees Schinus terebinthifolius Raddi (Aroeira-da-praia) and Myracrodruon urundeuva Allemão (Aroeira-do-sertão). Phytotherapy Research, 2013, 27(5), 692-698. Go to original source... Go to PubMed...
  10. Carlini EA, Duarte-Almeida JM, Rodrigues E, Tabach R. Antiulcer effect of the pepper trees Schinus terebinthifolius Raddi (aroeira-da-praia) and Myracrodruon urundeuva Allemão, Anacardiaceae (aroeira-do-sertão). Braz J Pharmacogn. 2010, 20(2), 140-146. Go to original source...
  11. Carvalho MC, Barca FN, Agnez-Lima LF, de Medeiros SR. Evaluation of mutagenic activity in an extract of pepper tree stem bark (Schinus terebinthifolius Raddi), Environ Mol Mutagen. 2003, 42(3), 185-191. Go to original source... Go to PubMed...
  12. Castro JA, Brasileiro BP, Lyra DH, Pereira DDA, Chaves JL, Amaral CLF. Ethnobotanical study of traditional uses of medicinal plants: The flora of caatinga in the community of Cravolândia-BA, Brazil J Med Plant Res. 2011, 5, 1905-1917.
  13. Cavalher-Machado SC, Rosas EC, Brito Fde A, et al. The anti-allergic activity of the acetate fraction of Schinus terebinthifolius leaves in IgE induced mice paw edema and pleurisy. Int Immunopharmacol. 2008, 8, 1552-1560. Go to original source... Go to PubMed...
  14. Ceruks M, Romoff P, Fávero OA, Lago JHG. Constituintes fenólicos polares de Schinus terebinthifolius Raddi (Anacardiaceae). Quim Nova. 2007, 30, 597-599. Go to original source...
  15. Correia AF, Silveira D, Fonseca-Bazzo YM, Magalhães PO, Fagg CW, da Silva EC, Gomes SM, Gandolfi L, Pratesi R, de Medeiros Nóbrega YK. Activity of crude extracts from Brazilian cerrado plants against clinically relevant Candida species. BMC Complement Altern Med. 2016, 16, 203. Go to original source... Go to PubMed...
  16. Crane E. Bees in Agriculture: When important honey plants are invasive weeds. Bee World, 1981, 62(1), 28-30. Go to original source...
  17. da Silva Dannenberg G, Funck GD, Mattei FJ, da Silva WP, Fiorentini ÂM. Antimicrobial and antioxidant activity of essential oil from pink pepper tree (Schinus terebinthifolius Raddi) in vitro and in cheese experimentally contaminated with Listeria monocyytogenes. Innovative Food Sci Emerg Technol. 2016, 36, 120-127. Go to original source...
  18. Dawkins K, Esiobu N. Emerging Insights on Brazilian Pepper Tree (Schinus terebinthifolius) Invasion: The Potential Role of Soil Microorganisms. Front Plant Sci. 2016, 7, 712. Go to original source... Go to PubMed...
  19. de Carvalho MCRD, Barca FNTV, Agnez-Lima LF, de Medeiros SRB. Evaluation of mutagenic activity in an extract of pepper tree stem bark (Schinus terebinthifolius Raddi). Enviro Molecular Mutag. 2003, 42(3), 185-191. Go to original source... Go to PubMed...
  20. Degener O. Flora Hawaiiensis (Books 1-4). Otto Degener, Riverdale, New York, 1946.
  21. Morton JF. Ornamental plants with poisonous properties. In Proceedings of the Florida State Horticultural Society. 1946, Vol. 71, pp. 372-380).
  22. de Lima MR, de Souza Luna J, dos Santos AF, de Andrade MC, Sant'Ana AE, Genet JP, Marquez B, Neuville L, Moreau N. Anti-bacterial activity of some Brazilian medicinal plants. J Ethnopharmacol. 2006, 105(1-2), 137-147.
  23. Díaz C, QuesadaS, Brenes O, Aguilar G, Cicció JF. Chemical composition of Schinus molle essential oil and ist cytotoxic activity on tumor cell lines. Nat Prod Res. 2008, 22(17), 1521-1534. Go to original source... Go to PubMed...
  24. Donnelly, M.J., Green, D.M., Walters, L.J. Allelopathic effects of fruits of the Brazilian pepper Schinus terebinthifolius on growth, leaf production and biomass of seedlings of the red mangrove Rhizophora mangle and the black mangrove Avicennia germinans. J Exp Marine Biol Ecol. 2008, 357(2), 149-156. Go to original source...
  25. do Rosário Martins M, Arantes S, Candeias F, Tinoco MT, Cruz-Morais J. Antioxidant, antimicrobial and toxicological properties of Schinus molle L. essential oils. J Ethnopharmacol. 2014, 151(1), 485-492. Go to original source... Go to PubMed...
  26. El-Massry KF, El-Ghorab AH, Shaaban HA, Shibamoto T. Chemical compositions and antioxidant/antimicrobial activities of various samples prepared from Schinus terebinthifolius leaves cultivated in Egypt. J Agr Food Chem. 2009, 57(12), 5265-5270. Go to original source... Go to PubMed...
  27. Ewel JJ. Invasibility: lessons from south Florida. In Ecology of biological invasions of North America and Hawaii (pp. 214-230). Springer New York, 1986. Go to original source...
  28. Ewel JJ, Ojima D, Karl D, Debusk W. Schinus in successional ecosystems of Everglades National Park. South Florida Res. Cent. Rep. T-676. Everglades National Park, National Park Service, Homestead, Florida, 1982.
  29. Gazzaneo, L.R.S., De Lucena, R.F.P., de Albuquerque, P.U. Knowledge and use of medicinal plants by local specialists in an region of Atlantic Forest in the state of Pernambuco (Northeastern Brazil). J Ethnobiol Ethnomed. 2005, 1, 9-15. Go to original source... Go to PubMed...
  30. Ghanney N, Rhouma A. Schinus terebinthifolius Raddi (Anacardiaceae) leaf extracts: Antibacterial activity against two Agrobacterium tumefaciens strains. Journal of Crop Protection, 2015, 4(1), 85-96.
  31. Gomes FS, Procópio TF, Napoleão TH, Coelho LC, Paiva PM. Antimicrobial lectin from Schinus terebinthifolius leaf. J Appl Microbiol. 2013, 114(3), 672-679. Go to original source... Go to PubMed...
  32. Gundidza M, Gweru N, Magwa ML, Mmbengwa V, Samie A. The chemical composition and biological activities of essential oil from the fresh leaves of Schinus terebinthifolius from Zimbabwe. African J Biotechnol. 2009, 8(24), 7164-7169.
  33. Hayashi T, Nagayama K, Arisawa M, Shimizu M, Suzuki S, Yoshizaki M, Morita N, Ferro E, Basualdo I, Berganza LH. Pentagalloylglucose, a xanthine oxidase inhibitor from a Paraguayan crude drug," Molle-i" (Schinus terebinthifolius). J Nat Prod. 1989, 52(1), 210-211. Go to original source... Go to PubMed...
  34. Jain MK, Yu BZ, Rogers JM, Smith AE, Boger ETA, Ostrander RL, Rheingold AL. Specific competitive inhibitor of secreted phospholipase A2 from berries of Schinus terebinthifolius. Phytochemistry. 1995, 39, 537-547. Go to original source... Go to PubMed...
  35. Johann S, Sá NP, Lima LARS, Cisalpino PS, Costa BB, Alves TMA, Siqueira EP, Zani CL. Antifungal activity of schinol and a new biphenyl compound isolated from Schinus terebinthifolius against the pathogenic fungus Paracoccidioides brasiliensis. Ann Clin Microbiol Antimicrob. 2010, 9, 30-35. Go to original source... Go to PubMed...
  36. Lamarque, L.J., Delzon, S., Lortie, C. J. Tree invasions: a comparative test of the dominant hypotheses and functional traits. Biological Invasions, 2011, 13, 1969-1989. Go to original source...
  37. Leite SR, Amorim MM, Sereno PF, Leite TN, Ferreira JA, Ximenes RA. Randomized clinical trial comparing the efficacy of the vaginal use of metronidazole with a Brazilian pepper tree (Schinus) extract for the treatment of bacterial vaginosis. Braz J Med Biol Res. 2011, 44(3), 245-252. Go to original source... Go to PubMed...
  38. Lima LB, Vasconcelos CFB, Maranhão HML, Leite VR, Ferreira PA, Andrade BA, Araújo EL, Xavier HS, Lafayette SSL, Wanderley AG. Acute and subacute toxicity of Schinus terebinthifolius bark extract. Journal of ethnopharmacology, 2009, 126(3), 468-473. Go to original source... Go to PubMed...
  39. Lindenmaier, D.S. [Etnobotânica em comunidades indígenas Guaranis no Rio Grande do Sul]. Santa Cruz do Sul: Universidade de Santa Cruz do Sul; 2008. Portuguese.
  40. Lorenzi H. Árvores Brasileiras: Manual de Identificação e Cultivo de Plantas Arbóreas Nativas do Brasil; Plantarum: São Paulo, Brazil, 1992, p. 384.
  41. Lucena PL, Ribas Filho JM, Mazza M, et al. [Evaluation of the aroreira (Schinus terebinthifolius Raddi) in the healing process of surgical incision in the bladder of rats]. Acta Cir Bras. 2006, 21 Suppl 2, 46-51. Portuguese. Go to original source... Go to PubMed...
  42. Machado DG, Kaster MP, Binfaré RW, Dias M, Santos ARS, Pizzolatti MG, Bringhenete IMC, Rodrigues ALS. Antidepressant-like effect of the extract from leaves of Schinus molle L. in mice: Evidence for the involvement of the monoaminergic system. Prog Neuropsychopharmacol Biol Psych. 2007, 31(2), 421-428. Go to original source... Go to PubMed...
  43. Mack, R.N. The commercial seed trade: an early disperser of weeds in the United States. Econom. Botany. 1991, 45, 257-273. Go to original source...
  44. Malca-García GR, Hennig L, Ganoza-Yupanqui ML, Piña-Iturbe A, Bussmann RW. (2016). Constituents from the bark resin of Schinus molle. Revista Brasileira de Farmacognosia. 2016, In press.
  45. Manrique, V., Cuda, J.P., Overholt, W.A. Brazilian peppertree: a poster child for invasive plants in Florida. J Florida Stud. 2013, 1, 1-14.
  46. Martínez MJ, Betancourt J, Alonso-González N, Jauregui A. Screening of some Cuban medicinal plants for antimicrobial activity. J Ethnopharmacol. 1996, 52(3), 171-174. Go to original source... Go to PubMed...
  47. Matsuo AL, Figueiredo CR, Arruda DC, et al. α-Pinene isolated from Schinus terebinthifolius Raddi (Anacardiaceae) induces apoptosis and confers antimetastatic protection in a melanoma model. Biochem Biophys Res Commun. 2011, 411, 449-454. Go to original source... Go to PubMed...
  48. Melo-Junior, EJ., Raposo, M.J., Lisboa, N.J.A., Diniz, M.F.A., Marcelino, C.A.C., Santana, A.E.G. Medicinal plants in the healing of dry socket in rats: microbiological and microscopic analysis. Phytomedicine. 2002, 9, 1109-1116.
  49. Moneam, N.M.A., Ghoneim, T. Gas chromatographic analysis of total 1 fatty acids extracted from S. terebinthifolius berries. J Chromatogr. 1986, 361, 391-395. Go to original source...
  50. Morton, J. F. Brazilian pepper - its impact on people, animals and the environment. Economic Botany, 1978, 32, 353-359. Go to original source...
  51. Morais TR, da Costa-Silva TA, Tempone AG, Borborema SE, Scotti MT, de Sousa RM, Araujo AC, de Oliveira A, de Morais SA, Sartorelli P, Lago JH. Antiparasitic activity of natural and semi-synthetic tirucallane triterpenoids from Schinus terebinthifolius (Anacardiaceae): structure/activity relationships. Molecules. 2014, 19(5), 5761-5776. Go to original source... Go to PubMed...
  52. Nocchi SR, de Moura-Costa GF, Novello CR, Rodrigues J, Longhini R, de Mello JC, Filho BP, Nakamura CV, Ueda-Nakamura T. In vitro Cytotoxicity and Anti-herpes Simplex Virus Type 1 Activity of Hydroethanolic Extract, Fractions, and Isolated Compounds from Stem Bark of Schinus terebinthifolius Raddi. Pharmacogn Mag. 2016, 12(46), 160-164. Go to original source... Go to PubMed...
  53. Panetta, F.D., McKee, J. Recruitment of the invasive ornamental, S. terebinthifolius, is dependent upon frugivores. Aust J Ecol. 1997, 22, 432-438. Go to original source...
  54. Pawlowski Â, Kaltchuk-Santos E, Zini CA, et al. Essential oils of Schinus terebinthifolius and S. molle (Anacardiaceae): Mitodepressive and aneugenic inducers in onion and lettuce root meristems. South Afric J Bot. 2012, 80, 96-103. Go to original source...
  55. Queires LCS, Fauvel-Lafève F, Terry S, De la Taille A, Kouyoumdjian JC, Chopin DK., Vacherot F, Rodrigues LEA, Crepin M. Polyphenols purified from the Brazilian aroeira plant (Schinus terebinthifolius, Raddi) induce apoptotic and autophagic cell death of DU145 cells. Anticancer Res. 2006, 26(1A), 379-387. Go to PubMed...
  56. Rosas EC, Correa LB, de Almeida Pádua T, Costa TEMM, Mazzei JL, Heringer AP, Bizarro CA, Kaplan MAC, Figueiredo MR, Henriques MG. Anti-inflammatory effect of Schinus terebinthifolius Raddi hydroalcoholic extract on neutrophil migration in zymosan-induced arthritis. Journal of ethnopharmacology, 2015, 175, 490-498. Go to original source... Go to PubMed...
  57. Santana JS, Sartorelli P, Guadagnin RC, Matsuo AL, Figueiredo CR, Soares MG, da Silva AM, Lago JHG. Essential oils from Schinus terebinthifolius leaves-chemical composition and in vitro cytotoxicity evaluation. Pharmaceutical Biology, 2012, 50(10), 1248-1253. Go to original source... Go to PubMed...
  58. Santana JS, Sartorelli P, Lago JHG, Matsuo AL. Isolamento e avaliação do potencial citotóxico de derivados fenólicos de Schinus terebinthifolius Raddi (Anacardiaceae). Quim. Nova. 2012, 35, 2245-2248. Go to original source...
  59. Santos ACAD, Rossato M, Agostini F, Serafini LA, Santos PLD, Molon R, Dellacassa E, Moyna P. Chemical composition of the essential oils from leaves and fruits of Schinus molle L. and Schinus terebinthifolius Raddi from Southern Brazil. J Essential Oil Bearing Plants, 2009, 12(1), 16-25. Go to original source...
  60. Schomourlo G, Mendonça-Fiho RR, Alviano CS, Costa SS. Screening of antifungal agents using ethanol precipitation and bio-autography of medicinal and food plants, J. Ethnopharmacol. 2005, 96(3), 563-568. Go to original source... Go to PubMed...
  61. Silva AB, Silva T, Franco ES, et al. Antibacterial activity, chemical composition, and cytotoxicity of leaf's essential oil from Brazilian pepper tree (Schinus terebinthifolius, Raddi). Brazilian J Microbiol. 2010, 41, 158-163. Go to original source... Go to PubMed...
  62. Silva, AG, Almeida DL, Ronchi S,N, et al. The essential oil of Brazilian pepper, Schinus terebinthifolia Raddi in larval control of Stegomyia aegypti (Linnaeus, 1762). Parasit Vectors. 2010, 3, 79. Go to original source... Go to PubMed...
  63. Uliana MP, Fronza M, da Silva AG, Vargas TS, de Andrade TU, Scherer R. (2016). Composition and biological activity of Brazilian rose pepper (Schinus terebinthifolius Raddi) leaves. Industrial Crops Products, 2016, 83, 235-240. Go to original source...
  64. Velásquez E, Tournier HA, Mordujovich de Buschiazzo P, Saavedra G, Schinella GR. Antioxidant activity of Paraguayan plant extracts. Fitoterapia. 2003, 74, 91-97. Go to original source... Go to PubMed...
  65. Vieira, R.F. Conservation of medicinal and aromatic plants in Brazil. In: Janick J, (eds) Perspectives on New Crops and New Uses. Alexandria (VA): ASHS Press, 1999, pp. 152-159.
  66. Youssef Moustafa AM, Kouam SF, Kulsoom A, Ejaz A, Ali S, Anjum S, Choudhary MI. Phytochemical investigation and biological evaluation of Schinus terebinthifolius, Res J Phytochem. 2007, 4(3), 162-172. Go to original source...
  67. Yueqin Z, Recio MC, Máñez S, Giner RM, Cerdá-Nicolás M, Ríos JL. Isolation of two triterpenoids and a biflavanone with anti-inflammatory activity from Schinus molle fruits. Planta Medica, 2003, 69(10), 893-898. Go to original source... Go to PubMed...