MMSL 2021, 90(2):54-60 | DOI: 10.31482/mmsl.2021.005

ANTIOXIDANTS IN PATIENTS LIVING WITH HIV ON ANTIRETROVIRALSOriginal article

Katerina Havlickova ORCID...1, Svatava Snopkova ORCID...1, Miroslav Pohanka ORCID...2, Radek Svacinka ORCID...1, Petr Husa j. ORCID...1, Filip Zlamal ORCID...3, Lenka Fabianova ORCID...4, Petr Husa ORCID...1
1 Department of Infectious Diseases, Faculty Hospital Brno and Faculty of Medicine, Masaryk University Brno, Czech Republic
2 Faculty of Military Health Sciences, University of Defense, Hradec Kralove, Czech Republic
3 Research Centre for Toxic Compounds in the Environment, Masaryk University Brno, Czech Republic
4 Department of Infectious Diseases, Masaryk Hospital Ústí nad Labem, Czech Republic

Oxidative stress is considered predictors of diseases associated with aging (cardiovascular disease, neurodegenerative disease, malignancies, and others) in HIV-negative general population. Antioxidants were investigated in people living with HIV on antiretroviral treatment to determine whether they had an immunosenescent phenotype that might predispose to the development of premature age-related diseases. Clinical studies in this population are controversial.

Methods: The study was conducted among 213 subjects with HIV, including 172 subjects on antiretro-virals and 41 subjects before the initiation of treatment. The control group consisted of healthy HIV-negative adults. We compared the reduced glutathione and ferric reducing antioxidant power levels in HIV untreated and treated patients and controls. Significant differences were determined by appropriate statistical tests (t - test, Mann–Whitney U test, Kolmogorov–Smirnov test, ANOVA, Kruskal–Wallis test). Relationships between continuous variables were quantified using Spearman’s rank correlation coefficient.

Results: Glutathione levels were significantly lower in the treated group compared with the untreated group and controls (P ˂ 0.001). Differences in total antioxidant levels between groups were not found.

Conclusions: Significant decrease of antioxidants was found independent of the virologic status of HIV patients on antiretroviral treatment. Persistence of these abnormal parameters may contribute and predispose to the premature development of diseases associated with aging.

Keywords: Antiretroviral therapy; glutathione; HIV; oxidative stress

Received: February 2, 2021; Revised: February 23, 2021; Accepted: February 23, 2021; Prepublished online: February 26, 2021; Published: June 4, 2021  Show citation

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Havlickova, K., Snopkova, S., Pohanka, M., Svacinka, R., j., P.H., Zlamal, F., Fabianova, L., & Husa, P. (2021). ANTIOXIDANTS IN PATIENTS LIVING WITH HIV ON ANTIRETROVIRALS. MMSL, 90(2), 54-60. doi: 10.31482/mmsl.2021.005
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