MMSL 2025, 94(1):2-9 | DOI: 10.31482/mmsl.2023.044

A POSSIBLE EFFECT OF EPIDURAL STEROID INJECTION ON COLLAGE TYPE II –α1 LEVEL IN PATIENTS WITH LOW BACK PAINOriginal article

Zainab R. Alqaseer ORCID...1, Ajil A. Alzamily ORCID...1*, Raad A. Alkhafaji2, Emad M. Hussain2, Thaier A. Alkhafaji2
1 College of Medicine, University of AL-Qadisiyah; Al-Diwaniyah, Iraq
2 Diwaniyah Health Department; Al-Diwaniyah Teaching Hospital, Al-Diwaniyah, Iraq

Background: Low back pain (LBP) is one of the common musckloskeletal diseases and usual treated by epidural steroid injection (ESI). ESIs improve patients' quality of life, reduce lumbar radicular pain, and postpone spinal surgery. The mechanism of improvement  is yet unscertain, perhaps involve type α collagen (COL2α) for bone maintenance, hence, we sought to investigate the role of injected steroids in bone healing focusing on the role of COL2α.

Methods: All patients in this research were diagnosed by specialists based on their histories and clinical features and associated diseaeses or compiling therapy. Serum samples collected from LBP patients and control group for comparisons.

Results: The present study found a significant (<0.0001) increase in the concentration of COL2α in patients with LBP after injection with ESI treatment compared with patients before injection and healthy individuals.

Conclusion: ESI helps LBP sufferers by boosting COL2α, which repairs damaged tissues.

Keywords: Steroids; Epidural injection; Collagen 2α; Low back pain; Lumbar radicular pain

Received: May 7, 2023; Revised: November 20, 2023; Accepted: December 15, 2023; Prepublished online: January 2, 2024; Published: March 3, 2025  Show citation

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Alqaseer, Z.R., Alzamily, A.A., Alkhafaji, R.A., Hussain, E.M., & Alkhafaji, T.A. (2025). A POSSIBLE EFFECT OF EPIDURAL STEROID INJECTION ON COLLAGE TYPE II –α1 LEVEL IN PATIENTS WITH LOW BACK PAIN. MMSL, 94(1), 2-9. doi: 10.31482/mmsl.2023.044
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