Vojenské Zdravotnické Listy, 2009 (vol. 78), issue 4

Colour Supplement

VZL 2009, 78(4):I-IV  

Evaluation of Cardiotoxicity of Oncology Treatment - Comparison of WHO and NCI Classification

Jan M. Horáček, Jana Mathonová, Miloš Tichý, Ladislav Jebavý

VZL 2009, 78(4):129-134  

Cardiac toxicity is one of the potential side effects of oncology treatment. For evaluation of cardiotoxicity, there is World Health Organization (WHO) classification, released in 1979, and National Cancer Institute (NCI) classification, updated in 2003. The article gives a review of possibilities for evaluation of cardiotoxicity using these two classifications.

Synthesis of Sterols in Polytrauma Injury

Pavel Vyroubal, Zdeněk Zadák, Radomír Hyšpler, Alena Tichá, Jaroslav Cerman, Jiří Bajnárek, Martin Hronek, Eduard Havel

VZL 2009, 78(4):135-142  

The study was clinical, monocentric and prospective. The aim of the study was to elucidate the role and importance of hypocholesterolemia in polytrauma.Material and Methods: A group of patients, who sustained polytrauma (n = 19), were recruited to the study. We performed the determination of sterols plasma levels and their precursors (beta-sitosterol, campesterol, lathosterol, skvalen), interleukin 6 (IL-6) and cortisol in the blood serum. The short version of ACTH stimulation test was performed. The oxidative burst of granulocytes was evaluated. The blood samples were taken on the day of admission, the first, the fourth and the eighth post-operative...

Human Granulocytic Ehrlichiosis - a New Tick-Borne Zoonosis by Us

Petr Knížek, Jiří Kobliha, František Sedláček

VZL 2009, 78(4):143-149  

Human granulocytic ehrlichiosis (HGE) is a new tick-borne zoonosis. HGE is caused by intracellular bakteria Anaplasma phagocytophila. The vector for this infection in Europe is the tick Ixodes ricinus. Typical clinical manifestations include fever, malaise, headache and myalgia. In more serious case gastrointestinal tract or respiratory and nervous systems may be affected. Characteristic laboratory abnormalities are leucopenia, thrombocytopenia and elevated liver transaminases. This disease can by confirmed by increasing of antibody titre (indirect immunofluorescence assay), microscopic identification of patogen in granulocytes from blood smear, eventually...

Sibutramine and Health-Related Quality of Life: Findings of Prospective, Longitudinal Study

Ladislav Slováček, Vladimír Pavlík

VZL 2009, 78(4):150-153  

Background: Obesity is a multifactorial, chronic disorder that has reached epidemic proportions in most industrialized countries and is threatening to become a global epidemic. Aims: The study evaluates the effect of sibutramine therapy on health-related quality of life of obese patients. Patients and Methods: The study is local, prospective and longitudinal. It was carried out at Department of Hygiene of Faculty of Military Health Sciences in Hradec Králové, Czech Republic. Data were obtained during the year 2007. Twenty-two obese patients (6 males and 16 females) were treated by sibutramine in dose of 10 mg/day. All of these 22 patients were aged...

Spatial Reconstruction of Histological Sections of the Temporal Bone

Bruno Ježek, Viktor Chrobok, Karel Antoš, Jan Vaněk

VZL 2009, 78(4):154-157  

Technical development in computer hardware and application of new visualization algorithms allow the use of spatial visualization methods in many different branches of biological research. Computer graphics and information visualization methods became important help in the research of spatial features of medical objects. The article describes the process of studied objects visualization, used methods, data structures and software tools. Temporal bone visualization case study shows reconstruction process from acquired image data to final rendering of created computer model. Obtained results prove the possibility to combine image, surface and volume...

Mitogen Activated Protein Kinases (MAPK), Ionising Radiation and Transcription Regulation

Jaroslav Pejchal, Jan Österreicher, Lenka Zárybnická, Zuzana Šinkorová, Aleš Tichý, Jiřina Vávrová

VZL 2009, 78(4):158-169  

Mitogen activated protein kinases (MAPK) are a superfamily of evolutionary-conserved eukaryotic kinases implicated in maintaining of cellular homeostasis. Ionising radiation impairs homeostasis and leads to time, dose and cellular specific compensatory MAPK activation. MAPK plays a critical role in modulation of gene expression that controls important cellular processes, such as proliferation, differentiation, cell survival, or apoptosis. This work discusses particular MAPK groups, their relation to ionising radiation and the mechanism which MAPK use to regulate processes of gene transcription.

The 13th Congress European Burns Association in Lausanne

Leo Klein, Monika Tokarik

VZL 2009, 78(4):170-171  

Report from the Congress International Surgical Week 2009

Zdeněk Šubrt, Alexander Ferko, Jiří Páral

VZL 2009, 78(4):172-173  

Report from the 23rd Annual Congress of the European Society for Vascular Surgery

Daniel Dobeš

VZL 2009, 78(4):173-174  

Ret. Col. Prof. MUDr. Štefan Petrovič, DrSc., 75-year-old

Ladislav Gerlich

VZL 2009, 78(4):175