VZL 2009, 78(4):158-169

Mitogen Activated Protein Kinases (MAPK), Ionising Radiation and Transcription Regulation

Jaroslav Pejchal ORCID...1, Jan Österreicher2, Lenka Zárybnická ORCID...2, Zuzana Šinkorová ORCID...2, Aleš Tichý ORCID...2, Jiřina Vávrová2
1 Univerzita obrany, Fakulta vojenského zdravotnictví, Centrum pokročilých studií, Hradce Králové
2 Univerzita obrany, Fakulta vojenského zdravotnictví, katedra radiobiologie, Hradce Králové

Mitogenem aktivované proteinové kinázy (MAPK) jsou superrodinou evolučně konzervovaných kináz eukaryotických buněk podílejících se na udržování buněčné homeostázy. Ionizující záření stabilitu vnitřního prostředí narušuje a tím vede k časově, dávkově a buněčně specifické kompenzatorní aktivaci MAPK. MAPK následně sehrávají kritickou úlohu v modulaci buněčného programu genové exprese, jejímž prostřednictvím reguluje tak důležité biologické děje, jakými jsou proliferace, diferenciace, přežití buněk či naopak apoptóza. Tato práce pojednává o jednotlivých skupinách MAPK, jejich vztahu k ionizujícímu záření a mechanizmu, jakým mohou MAPK zasahovat do procesu genové transkripce.

Keywords: MAPK; Ionizující záření; Transkripce

Mitogen activated protein kinases (MAPK) are a superfamily of evolutionary-conserved eukaryotic kinases implicated in maintaining of cellular homeostasis. Ionising radiation impairs homeostasis and leads to time, dose and cellular specific compensatory MAPK activation. MAPK plays a critical role in modulation of gene expression that controls important cellular processes, such as proliferation, differentiation, cell survival, or apoptosis. This work discusses particular MAPK groups, their relation to ionising radiation and the mechanism which MAPK use to regulate processes of gene transcription.

Keywords: MAPK; Ionising radiation; Transcription

Received: May 25, 2009; Published: December 1, 2009  Show citation

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Pejchal, J., Österreicher, J., Zárybnická, L., Šinkorová, Z., Tichý, A., & Vávrová, J. (2009). Mitogen Activated Protein Kinases (MAPK), Ionising Radiation and Transcription Regulation. Vojenské Zdravotnické Listy, 78(4), 158-169
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