Vojenské Zdravotnické Listy, 2010 (vol. 79), issue 2
Colour Supplement
VZL 2010, 79(2):I-IV 
Editorial
Kamil Kuča
VZL 2010, 79(2):45
New Bisquaternary Inhibitors of Acetylcholinesterase Used as a Profylactics in Organophosphorus Poisoning
Růžena Pavlíková, Jan Marek, Kamil Musílek, Josef Fusek, Kamil Kuča, Jana Žďárová Karasová
VZL 2010, 79(2):46-49
The prophylactic antidotes are pharmaceutics which can prevent the intoxication of the human body or may improve its prognosis if administered before the exposure to a toxic substance. Pyridostigmine chloride, a reversible acetylcholinesterase(AChE) inhibitor, is used as a prophylactic antidote which may prevent the organism from organophosphorus poisoning (OP). This paper is focused on searching new AChE inhibitors that might be used in prophylactic treatment of OP intoxications. The aim of this study was to prepare 15 symmetric bisquaternary inhibitors and to evaluate their inhibition ability (IC50) via a standard in vitro method. The but-(2E)-en-1,4-diyl-1,1'-bis(4-(4-nitrobenzyl)-pyridinium)...
Beta-Amino Acids and Their Natural Biologically Active Derivatives. II. Derivatives of Beta-Lysine and Beta-Arginine
Jiří Patočka
VZL 2010, 79(2):50-53
On contrary to proteinogenic α-amino acids that are constituents of all proteins and enzymes which control the metabolism in living matter, β-amino acids, which are less abundant than their α-isomers, mostly occur as constituents of distinct natural products, such as peptides, cyclopeptides, depsipeptides, glycopeptides, alkaloids, or terpenoids. Especially bacteria, cyanobacteria, fungi, and some of plants often incorporate β-amino acids into secondary metabolites. These serve as tools to secure their survival in competition with other organism. Therefore, these compounds are often characterized by potent biological activities...
"Sweet" World of Bacteria: Methodical Approaches Used in Bacterial Glycoproteins Analysis
Lucie Balonová, Lenka Hernychová, Zuzana Bílková, Jiří Stulík
VZL 2010, 79(2):54-59
Protein glycosylation plays an important role in the pathogenicity of certain bacteria. In this article, we provide an overview of up-to-date analytical methods, which are utilized in the analysis of protein glycosylation of eukaryotic origin. The methods with experimentally verified modifications can be applied in a study of prokaryotic glycoproteins as well.
Introduction to Laboratory Experiments Statistics
Miroslav Pohanka
VZL 2010, 79(2):60-63
Appropriate application of statistics is an unsubstitutable aspect of laboratory assay in research and development as well as clinical labs. Performance of good statistical methods and understanding of experiments in point of view of the achieved data interpretation is frequently poor. The present compilation includes basic statistical methods necessary for good comprehension of laboratory assay. The definitions such as precision and accuracy, limit of detection, limit of quantification, correlation, sensitivity, deviation and calibration are included in the text.
Biodosimetric Methods
Jaroslav Pejchal, Jan Österreicher, Lenka Zárybnická, Zuzana Šinkorová, Aleš Tichý, Jiřina Vávrová
VZL 2010, 79(2):64-71
Biodosimetry has recently become a quickly developing subject of radiobiology. Its significance has been increasing regarding nuclear ambitions of Iran and Democratic People's Republic of Korea and instable situation in Pakistan, where, if the Taliban wins, the radical movement will be in the possession of Pakistan nuclear arsenal and, according to its leaders, will not hesitate to use it. In the situation of nuclear weapon use, biodosimetry serves as a tool for accident assessment which enables optimization of emergency rescue system responses and prediction of consequences.The text is an overview of basic biodosimetric approaches used in radiation...
Chlorine Trifluoride - Atypical Lung Injurant Agent
Jiří Patočka, Zdeněk Hon
VZL 2010, 79(2):72-75
Chlorine trifluoride is nonflammable, corrosive, and nearly colourless gas with a sweet odour. This compound is extremely reactive. Chlorine trifluoride is hazardous chemical highly irritating the skin, eyes, and mucous membranes. There are no valid human studies in which well characterized exposure to inhalation of ClF3 is related to systemic effects but data from inhalation experiments in laboratory rats and dogs indicate that eyes and respiratory tract are the target organs following acute and repeated exposure to chlorine trifluoride. The current OSHA permissible exposure limit (PEL) for chlorine trifluoride is 0.1 ppm of air as a ceiling limit....
Ethical Aspects of Triage
Bernd Domres, Tobias Kees, Stefan Gromer, Peter Braitmaier, Tanja Granzow
VZL 2010, 79(2):76-82
The discipline of medical ethics is concerned with morality, moral obligations and the principles of proper professional conduct concerning the rights and duties of a physician himself, his patients and fellow practitioners, as well as his actions in the care of patients and in relation with their families. Its foundations lie in the philosophical traditions of Eastern and Western thought and have strongly shaped modern codes of conduct and conventions...
A Short Review of the Czech Army Field Hospital Activity in Afghanistan in 2007-2008
Josef Roubal, M. Benda, Jiří Páral, Michal Plodr
VZL 2010, 79(2):83-86
This article describes activities of the Czech Field Hospital of The Army of the Czech Republic in 2007-2008. The article briefly summarizes historical, geographical and demographic information about Afghanistan. Hospital facilities, structure of medical teams, and medical and humanitarian work of the teams are described there.
Ret. Colonel Prof. MUDr. Vratislav Hrdina, CSc., died
Jiří Bajgar, Josef Fusek, František Dohnal
VZL 2010, 79(2):87