MMSL, 2013 (vol. 82), issue 1
BINDING OF QUATERNARY AMMONIUM SALTS TO ACETYLCHOLINE RECEPTORS: POSSIBLE CHEMICAL WARFARE NERVE AGENTSReview article
James C. Ball
MMSL 2013, 82(1):2-24 | DOI: 10.31482/mmsl.2013.001 
Classical chemical nerve agents are organophosphate based compounds such as Sarin, Soman, Tabun, VX and others. These compounds inhibit acetylcholinesterases in the synapses of nerve junctions. Instead of inactivating acetylcholinesterases, compounds, quaternary amines, can block nerve transmission by binding primarily to the acetylcholine receptor sites. The U.S. Patent Office has published 23 unique patents or invention registrations on the synthesis of compounds that can bind to muscarinic and nicotinic acetylcholine receptors. It is likely that some of these compounds could serve as either polarizing or nonpolarizing nerve agents that bind to the...
ADVANTAGES AND DISADVANTAGES OF TRANSABDOMINAL PREPERITONEAL APPROACH AND TOTAL EXTRAPERITONEAL APPROACH VERSUS OPEN REPAIR OF INGUINAL HERNIAReview article
Radek Pohnán, Faye Rozwadowski, Leo Klein, Miroslav Ryska
MMSL 2013, 82(1):25-31 | DOI: 10.31482/mmsl.2013.002
Surgical repair of inguinal hernias is one of the most common surgical procedures performed. Since endoscopic inguinal hernia repair was first reported in 1990, the operation has been refined into an attractive alternative to open hernia repair for many patients and surgeons. Transabdominal preperitoneal approach (TAPP) and total extraperitoneal approach (TEP) are the most commonly used methods for miniinvasive inguinal hernia treatment. Employing the electronic databases MEDLINE, Pubmed and Ebscohost, these methods were compared with open techniques. Perioperative and postoperative complications, recurrent hernias and quality of life were evaluated....
TOXIC POTENTIAL OF SUPERWARFARIN: BRODIFACOUMReview article
Jiří Patočka, Georg Petroianu, Kamil Kuča
MMSL 2013, 82(1):32-38 | DOI: 10.31482/mmsl.2013.003
Brodifacoum, a commercially available, long-acting anticoagulant rodenticide, is a highly toxic compound. Structurally it is similar to warfarin, but it is many times more potent, with the ability to cause severe bleeding in humans. Most of the health hazards of brodifacoum are associated with accidental ingestion. Superwarfarin intoxication may have no signs or symptoms other than bleeding at various sites. Brodifacoum has the potential to be used as a chemical warfare agent because of its high potency and long duration of action.
THE FIRST MEDEVAL CERTIFICATE FOR THE CZECH ARMED FORCES FIELD HOSPITALLetter to the editor
Jan Österreicher
MMSL 2013, 82(1):39-40
Dear Sir, I would like to inform you, that, recently, scientific and educative effort of the Medical Corps of the Czech Armed Forces has achieved a significant result in the quality, deployability and sustainability process within field medical support area. Until 2010, all field military hospital units were certified according to the CREVAL scale considering deployability from logistic and military-operation aspects only. CREVAL scale has been omitting medical aspects, number of medical specialists and procedures for proper triage, treatment ...
CONGRESS "RESUSCITATION 2012 - WORKING TOGETHER TO SAVE LIVES" IN VIENNALetter to the editor
Miroslav Lastič
MMSL 2013, 82(1):41-43
The European Resuscitation Council (ERC) is an interdisciplinary council for resuscitation medicine and emergency medical care. The main goal of this organization is to save the life and on the basis of knowledge and experiences to ensure high quality of resuscitation available to all. Preparation, development and publication of resuscitation guidelines for Europe (Guidelines 2010 lastly), organization of courses for both, lay- and professional rescuers, and organization of congresses, are the key activities of the ERC. The program of this year's Congress was built with the intention to promote new technologies (especially cooling, feedback device...
OBITUARY - RNDr. MARIE VACKOVÁ, Ph.D.Letter to the editor
Miroslav Špliňo
MMSL 2013, 82(1):44
Dr. Vackova, resident of Hradec Kralove, Czech Republic, passed away October 11, 2012 as a result of a long battle with serious illness. Dr. Vackova was born in Policka, Czech Republic in 1953. She went School of Nursing and Pharmaceutical Faculty in Hradec Kralove. After completing her degree she joined Department of Epidemiology, the Military Medical Research Institute in Hradec Kralove. All the time she successfully participated in research projects of the microbiological laboratory, e.g. the selective contamination GIT in immunosuppressed patients. She defended her doctoral thesis in the end of 1992. Dr. Vackova devoted to the European ...