MMSL 2011, 80(2):80-84 | DOI: 10.31482/mmsl.2011.012

ON THE UNIVERSALITY OF OXIME HLö-7 - ANTIDOTE FOR CASE OF THE NERVE AGENT POISONINGOriginal article

Kamil Kuča ORCID...1,2*, Kamil Musílek ORCID...2,3, Jana Karasová2,4, Daniel Jun ORCID...2, Ondřej Soukup ORCID...1,2, Miroslav Pohanka ORCID...1,2, Kallol Kumar Ghosh5, Martina Hrabinová ORCID...1
1 Center of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
2 University Hospital, Hradec Kralove, Czech Republic
3 University of Hradec Kralove, Faculty of Science, Department of Chemistry, Hradec Kralove, Czech Republic
4 Department of Public Health, Faculty of Military Health Sciences, University of Defence, Hradec Kralove, Czech Republic
5 School of Studies in Chemistry, Pt. Ravishankar Shukla University, Raipur (C.G.), India

Searching for the universal oxime, which could be able to reactivate acetylcholinesterase inhibited by various nerve agents is still topic of high interest. In this contribution, oxime HLö-7, that was thoroughly discussed in the last decade, is evaluated . Its universality was tested in vitro using the rat brain homogenate as a source of the cholinesterases. The main members of the nerve agent family (tabun, sarin, soman, cyclosarin and VX) were used for this purpose. As shown, oxime HLö-7 was able to reactivate cholinesterases inhibited by all tested nerve agents with the exception of tabun. Hence, it could not be designated as the broad-spectrum reactivator.

Keywords: oxime; HLö-7; reactivator; nerve agent; acetylcholinesterase; antidote

Received: April 12, 2011; Revised: May 29, 2011; Published: June 10, 2011  Show citation

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Kuča, K., Musílek, K., Karasová, J., Jun, D., Soukup, O., Pohanka, M., Kumar Ghosh, K., & Hrabinová, M. (2011). ON THE UNIVERSALITY OF OXIME HLö-7 - ANTIDOTE FOR CASE OF THE NERVE AGENT POISONING. MMSL, 80(2), 80-84. doi: 10.31482/mmsl.2011.012
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