MMSL 2012, 81(1):27-39 | DOI: 10.31482/mmsl.2012.004

INTRACELLULAR PATHOGENESIS OF FRANCISELLA TULARENSISReview article

Adéla Strašková1*, Jiří Stulík ORCID...2
1 Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Hradec Králové, Czech Republic
2 Institute of Molecular Pathology, Faculty of Military Health Sciences, University of Defence, Hradec Králové, Czech Republic

Intracellular pathogen F. tularensis is a causative agent of tularemia disease and belongs to the most hazardeous pathogen worldwide, categorized by the Center for Disease Control and Prevention, USA (CDC) as a category A agent. However, no safe and licensed vaccine for prevention a F. tularensis infection is available for vaccination. Tularemia is manifested by several forms depending on a route of infection and virulence of a F. tularensis strain. Essential to a development of the disease is the ability to infect, survive and proliferate inside the mononuclear phagocytes, such as macrophages or dendritic cells. Therefore, this review will discuss aspects of F. tularensis intracellular fate within host macrophages, modulate host signaling pathways to benefit Francisella infection and finally, summarize bacterial determinats involved in the process of phagosomal escape and intracellular replication.

Keywords: Francisella tularensis; tularemia; intracellular trafficking; phagosome; intracellular replication; macrophage; Francisella Pathogenicity Island; virulence

Received: February 7, 2012; Revised: February 12, 2012; Published: March 9, 2012  Show citation

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Strašková, A., & Stulík, J. (2012). INTRACELLULAR PATHOGENESIS OF FRANCISELLA TULARENSIS. MMSL, 81(1), 27-39. doi: 10.31482/mmsl.2012.004
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