MMSL 2012, 81(2):76-81 | DOI: 10.31482/mmsl.2012.010

SYNTHESIS OF THE ISOQUINOLINIUM SALTS DIFFERING IN THE LENGTH OF THE SIDE ALKYLATING CHAINOriginal article

Jan Marek ORCID...1,3,4*, Petr Stodůlka2, Ondřej Soukup ORCID...5, Kamil Musílek ORCID...1,5,6, Jiří Cabal1, Kamil Kuča ORCID...2,5
1 Department of Toxicology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, Hradec Kralove, 50001, Czech Republic
2 Centre of Advanced Studies, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, Hradec Kralove, 50001, Czech Republic
3 Department of Epidemiology, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, Hradec Kralove, 50001, Czech Republic
4 Vakos XT, Pernerova 28a, Prague, 18600, Czech Republic
5 Biomedical Research Center, University Hospital Hradec Kralove
6 Department of Chemistry, Faculty of Science, University of Hradec Kralove, Rokitanskeho 62, 50003, Hradec Kralove, Czech Republic

Cationic tensides are a widespread group of surface active agents. These compounds have lots of applications in various branches of industry and research. Quaternary isoquinolinium salts differing in alkyl chain length are members of a cationic surfactant group with quaternary nitrogen in its structure. The members of this group can be used as micellar catalysts or disinfectants. Decontamination (chemical warfare agents) or disinfection (bacteria or fungi) for very similar compounds was described several times. In this work, the preparation of isoquinoline-derived cationic surfactants differing in the length of the side alkylating chain from C8 to C20 is described. An HPLC method used for distinction of all prepared long-chain isoquinolinium analogues has been successfully developed.

Keywords: isoquinolinium salts; synthesis, HPLC; surfactants; disinfection; decontamination

Received: April 1, 2012; Revised: May 18, 2012; Published: June 8, 2012  Show citation

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Marek, J., Stodůlka, P., Soukup, O., Musílek, K., Cabal, J., & Kuča, K. (2012). SYNTHESIS OF THE ISOQUINOLINIUM SALTS DIFFERING IN THE LENGTH OF THE SIDE ALKYLATING CHAIN. MMSL, 81(2), 76-81. doi: 10.31482/mmsl.2012.010
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