MMSL 2014, 83(1):34-39 | DOI: 10.31482/mmsl.2014.006

RAPID INFORMATIVE SCREENING OF NANO-ALAPTIDE AS POTENTIAL TRANSDERMAL PERMEATION ENHANCER OF ACETYLSALICYLIC ACID AND PARACETAMOLOriginal article

Aneta Černíková, Radka Opatřilová, Josef Jampílek*
Department of Chemical Drugs, Faculty of Pharmacy, University of Veterinary and Pharmaceutical Sciences, Palackeho 1/3, 61242 Brno, Czech Republic

This investigation deals with the affection of permeation of acetylsalicylic acid and paracetamol applied in the system propylene glycol-water 1:1 through full-thickness pig ear skin by alaptide that was applied in nanonized form as a potential chemical penetration enhancer. Alaptide, (S)-8-methyl-6,9-diazaspiro[4.5]decan-7,10-dione, is the original Czech compound. The application of nanonized alaptide significantly enhanced the permeation of both drugs through the skin. Enhancement ratios in the studied time interval 0.5-2.0 h varied from 1.11 to 17.70 for acetylsalicylic acid and from 6.83 to 19.83 for paracetamol.

Keywords: alaptide; nanoparticles; chemical penetration enhancer; acetylsalicylic acid; paracetamol

Received: January 6, 2014; Revised: March 17, 2014; Published: April 7, 2014  Show citation

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Černíková, A., Opatřilová, R., & Jampílek, J. (2014). RAPID INFORMATIVE SCREENING OF NANO-ALAPTIDE AS POTENTIAL TRANSDERMAL PERMEATION ENHANCER OF ACETYLSALICYLIC ACID AND PARACETAMOL. MMSL, 83(1), 34-39. doi: 10.31482/mmsl.2014.006
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