MMSL, 2013 (vol. 82), issue 2
18th INTERDISCIPLINARY CZECH-SLOVAK TOXICOLOGY CONFERENCE - TOXCON 2013Meeting abstracts
Kamil Kuča
MMSL 2013, 82(2) 
Dear Readers,this special issue of our journal, Military Medical Science Letters, is aimed at the summary of meeting abstracts presented at the 18th Interdisciplinary Czech-Slovak Toxicology Conference - TOXCON 2013. This meeting was held in Hradec Kralove, Czech Republic, from 19th to 21st June 2013. This particular meeting was organized by Czech Society for Experimental and Clinical Pharmacology and Toxicology and Slovak Toxicology Society with the support of the University hospital Hradec Kralove, Faculty of Medicine, Charles University Hradec Kralove and Faculty of Military Health Sciences, University of Defence...
HOW MILITARY HOSPITALS GET READY FOR CHEMICAL WEAPON VICTIMSReview article
Levent Kenar, Mesut Ortatatli
MMSL 2013, 82(2):46-54 | DOI: 10.31482/mmsl.2013.007
The deliberate use of chemical weapons has emerged as a significant threat especially in last decades, mainly after the terrorist attack on 11th September 2011, and the use of these agents in future wars and terror attacks still remains a realistic concern. Despite the existence of many conventions and aggreements like Chemical Weapons Convention and 1925 Geneva Protocol against the use of chem-bio weapons, they have been used in many wars and conflicts. From this point of view, other than civilian state hospitals, military hospitals should be aware and get prepared to manage the victims injured due to chemical weapons. Military hospitals...
SCREENING OF BLOOD-BRAIN BARRIER PENETRATION USING THE IMMOBILIZED ARTIFICIAL MEMBRANE PHOSPHATIDYLCHOLINE COLUMN CHROMATOGRAPHY AT THE PHYSIOLOGICAL PHOriginal article
Jana ®ďárová Karasová, Daniel Jun, Kamil Kuča
MMSL 2013, 82(2):55-62 | DOI: 10.31482/mmsl.2013.008
In this study, 21 structurally diverse drugs with examined central nervous system penetration were used for prediction of blood-brain barrier penetration using HPLC-UV instrument. Drugs' chromatographic capacity factors were measured by the immobilized artificial membrane presented by phosphatidylcholine column. The correlation between chromatographic capacity factor, octanol-water partition coefficient (log P) and molecular polar surface area (PSA) were determined at the physiological pH. The correlation factor 0.6677 with respect to log P and 0.7199 in reference to PSA was assigned. The developed in vitro prediction method may be used as a...
MICROREACTOR TECHNOLOGY IN WARFARE AGENT CHEMISTRYOriginal article
Andreas Zaugg, Julien Ducry, Christophe Curty
MMSL 2013, 82(2):63-68 | DOI: 10.31482/mmsl.2013.009
Even though the use of microreactors for synthesising classical chemical warfare agents or other compounds scheduled in the CWC (Chemical Weapons Convention) has not been published to date, the new technology has attracted the attention of the organic chemistry group of SPIEZ LABORATORY. Studies of the group show that in a few areas and sectors of chemistry, microreactors can provide a good alternative to the batch procedure. In classic warfare chemistry however, the technology can bring no benefits, since many reactions pro-duce a solid and are thus entirely unsuitable for microreactors.
ANTHRAX COUNTER MEASURES 2013 INTERNATIONAL CONFERENCE PROCEEDINGS, ROYAL UNITED SERVICES INSTITUTE, LONDON, 4 FEBRUARY 2013Meeting abstracts
S.S. Vasan et al.
MMSL 2013, 82(2):69-86
Anthrax is still a high threat biological agent, with historical precedence of potential terrorist use. While lack of human-to-human transmission may contain attacks in pockets, attacks can be multiple, coordinated and/or covert, therefore successful containment is heavily dependent on rapid identification after the smallest (possible) number of early cases, immediate and accurate statistical assessment of its geographic extent based on case histories, and a rapidly targeted prophylaxis strategy that considers both antibiotics and vaccine. Persistence of spores could lead to continued post-event threat, lack of guarantee that total decontamination...
WORKSHOP IN HRADEC KRÁLOVÉ, CZECH REPUBLIC, ON STATES OF PREPAREDNESS FOR MASS-CASUALTY SITUATIONSLetter to the editor
Leo Klein, Vlasta Neklapilová
MMSL 2013, 82(2):87-91
On 28th November 2012, the Social Health Academy, the Regional Emergency Medical Service, and the Department of Military Surgery at the University of Defence together held a workshop on States of Preparedness for Emergency- and Mass-Casualty Situations (MCS). The speakers were Dr. Moshe Michaelson (Director, Teaching Centre for Trauma, Emergency and Mass-Casualty Situations) and Mrs. Gila Hyams, RN (Director of Nursing and Trauma Co-ordinator) at the Rambam Hospital in Haifa, Israel. Altogether, thirty medical ...
TOXCON 2013Announcement
Kamil Kuča
MMSL 2013, 82(2):92
University Hospital Hradec Králové in cooperation with Faculty of Medicine, Charles University, Hradec Králové, Faculty of Military Health Sciences, University of Defense, Hradec Králové organizing 18th Interdisciplinary Czech-Slovak Toxicology Conference TOXCON 2013.